Recombinant Full Length Human CNOT7 Protein, C-Flag-tagged

• Cat.No.: CNOT7-358HFL
• Product Overview: Recombinant Full Length Human CNOT7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 32.6 kDa
• AA Sequence: MPAATVDHSQRICEVWACNLDEEMK KIRQVIRKYNYVAMDTEFPGVVARP IGEFRSNADYQYQLLRCNVD LLKIIQLGLTFMNEQGEYPPGTSTW QFNFKFNLTEDMYAQDSIELLTTSG IQFKKHEEEGIETQYFAELL MTSGVVLCEGVKWLSFHSGYDFGYL IKILTNSNLPEEELDFFEILRLFFP VIYDVKYLMKSCKNLKGGLQ EVAEQLELERIGPQHQAGSDSLLTG MAFFKMREMFFEDHIDDAKYCGHLY GLGSGSSYVQNGTGNAYEEE
  ANKQSTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transcription Factors
• Protein Pathways: RNA degradation

Gene Information

• Gene Name: CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]
• Official Symbol: CNOT7
• Synonyms: CAF1; CAF-1; Caf1a; hCAF-1
• Gene ID: 29883
• mRNA Refseq: NM_013354.7
• Protein Refseq: NP_037486.2
• MIM: 604913
• UniProt ID: Q9UIV1