Recombinant Full Length Human CNR1 Protein, GST-tagged

• Cat.No.: CNR1-1958HF
• Product Overview: Human CNR1 full-length ORF ( NP_057167.2, 1 a.a. - 472 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 79.3 kDa
• Protein Length: 472 amino acids
• AA Sequence: MKSILDGLADTTFRTITTDLLYVGS NDIQYEDIKGDMASKLGYFPQKFPL TSFRGSPFQEKMTAGDNPQLVPADQ VNITEFYNKSLSSFKENEENIQCGE NFMDIECFMVLNPSQQLAIAVLSLT LGTFTVLENLLVLCVILHSRSLRCR PSYHFIGSLAVADLLGSVIFVYSFI DFHVFHRKDSRNVFLFKLGGVTASF TASVGSLFLTAIDRYISIHRPLAYK RIVTRPKAVVAFCLMWTIAIVIAVL PLLGWNCEKLQSVCSDIFPHIDETY LMFWIGVTSVLLLFIVYAYMYILWK AHSHAVRMIQRGTQKSIIIHTSEDG KVQVTRPDQARMDIRLAKTLVLILV VLIICWGPLLAIMVYDVFGKMNKLI KTVFAFCSMLCLLNSTVNPIIYALR SKDLRHAFRSMFPSCEGTAQPLDNS MGDSDCLHKHANNAASVHRAAESCI KSTVKIAKVTMSVSTDTSAEAL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CNR1 cannabinoid receptor 1 (brain) [ Homo sapiens ]
• Official Symbol: CNR1
• Synonyms: CNR1; cannabinoid receptor 1 (brain); CNR; cannabinoid receptor 1; CANN6; CB R; CB1; CB1A; CB1K5; central cannabinoid receptor; CB-R; CB1R
• Gene ID: 1268
• mRNA Refseq: NM_001160226
• Protein Refseq: NP_001153698
• MIM: 114610
• UniProt ID: P21554

Reviews

08/18/2022

DNA binding ability is strong, and it performs well in related experiments.

04/24/2022

The immunogenicity is very weak, does not cause an immune response, and has a high safety profile.

04/09/2022

CNR1 has a long shelf life and good stability, which is convenient for the continuity of subsequent experiments.

Q&As

What are the mechanisms of action of CNR1 receptor agonists and antagonists?

The protein receptor agonists can bind to receptors, activate receptors, and promote their signal transduction, resulting in physiological effects. CNR1 receptor antagonists, on the other hand, can bind to the receptor and prevent endocannabinoids from binding to the receptor, thereby inhibiting its signal transduction.

What are the types of CNR1 mutations?

There are many types of mutations in the CNR1 gene, including single nucleotide substitution, insertion, or deletion. These mutations may cause structural and functional changes in the CNR1 receptor, affecting its binding and signal transduction to endocannabinoids.

What role does the CNR1 receptor play in neuronal connections and neural circuits?

CNR1 receptors play an important role in neuronal connections and neural circuits. It is involved in the growth, differentiation, and synapse formation of neurons, as well as in the regulation of neural circuits and signal transduction.

How about the potential applications of the CNR1 receptor in drug development?

CNR1 receptors have potential applications in drug development. Some studies have shown that CNR1 receptor agonists or antagonists can be used to treat neurological disorders such as pain, depression, and anxiety.

Does the CNR1 gene polymorphism affect individual differences?

Polymorphisms in the CNR1 gene may cause differences in individual responses to medications. Some polymorphisms may increase an individual's sensitivity or tolerance to medications, which can affect the efficacy and safety of medications.

Do environmental factors influence CNR1 gene expression?

For example, some drugs, toxins, or stressors may affect the expression level of the CNR1 gene, thus affecting its function and signal transduction processes.