Recombinant Full Length Human CRBN Protein, N-Flag-tagged
Cat.No. : | CRBN-13HFL |
Product Overview : | Recombinant Full Length Human CRBN Protein, fused to Flag-tag at N-terminus, was expressed in HEK293T. |
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- Gene Information
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Description : | The Cereblon (CRBN) protein via its interaction with the DNA damage-binding protein-1 (DDB1), Cullin 4 (Cul4A or Cul4B), and regulator of Cullins 1 (RoC1) forms a functional E3 Ub ligase complex. In this complex, Cereblon functions as a substrate receptor that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Like most E3 ligases, Cereblon complex ubiquitinates itself and its auto-ubiquitination promotes its ligase activity. Cereblon complex is involved in many biological processes including cell proliferation and apoptosis, and it has been extensively used in targeted protein degradation (PROTAC®), where CRBN binds to the protein of interest and leads to its degradation. This approach has shown promising results in the treatment of cancer. |
Source : | HEK293T |
Species : | Human |
Tag : | N-Flag |
Protein length : | 2-422 aa(end) |
Form : | Aqueous buffer solution. 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 100 μg ml FLAG peptide. |
Molecular Mass : | 51 kDa |
Purity : | ≥70% |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | -80 centigrade |
Concentration : | 0.31 mg/ml |
Use/Stability : | At least 6 months at -80 centigrade. Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles. |
Gene Name : | CRBN cereblon [ Homo sapiens (human) ] |
Official Symbol : | CRBN |
Synonyms : | CRBN; cereblon; AD-006; MRT2; MRT2A |
Gene ID : | 51185 |
mRNA Refseq : | NM_016302.4 |
Protein Refseq : | NP_057386.2 |
MIM : | 609262 |
UniProt ID : | Q96SW2 |
Products Types
◆ Lysates | ||
CRBN-395HCL | Recombinant Human CRBN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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