Recombinant Full Length Human CSE1L Protein, C-Flag-tagged

• Cat.No.: CSE1L-212HFL
• Product Overview: Recombinant Full Length Human CSE1L Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 110.2 kDa
• AA Sequence: MELSDANLQTLTEYLKKTLDPDPAI RRPAEKFLESVEGNQNYPLLLLTLL EKSQDNVIKVCASVTFKNYI KRNWRIVEDEPNKICEADRVAIKAN IVHLMLSSPEQIQKQLSDAISIIGR EDFPQKWPDLLTEMVNRFQS GDFHVINGVLRTAHSLFKRYRHEFK SNELWTEIKLVLDAFALPLTNLFKA TIELCSTHANDASALRILFS SLILISKLFYSLNFQDLPEFFEDNM ETWMNNFHTLLTLDNKLLQTDDEEE AGLLELLKSQICDNAALYAQ KYDEEFQRYLPRFVTAIWNLLVTTG QEVKYDLLVSNAIQFLASVCERPHY KNLFEDQNTLTSICEKVIVP NMEFRAADEEAFEDNSEEYIRRDLE GSDIDTRRRAACDLVRGLCKFFEGP VTGIFSGYVNSMLQEYAKNP SVNWKHKDAAIYLVTSLASKAQTQK HGITQANELVNLTEFFVNHILPDLK SANVNEFPVLKADGIKYIMI FRNQVPKEHLLVSIPLLINHLQAES IVVHTYAAHALERLFTMRGPNNATL FTAAEIAPFVEILLTNLFKA LTLPGSSENEYIMKAIMRSFSLLQE AIIPYIPTLITQLTQKLLAVSKNPS KPHFNHYMFEAICLSIRITC KANPAAVVNFEEALFLVFTEILQND VQEFIPYVFQVMSLLLETHKNDIPS SYMALFPHLLQPVLWERTGN IPALVRLLQAFLERGSNTIASAAAD KIPGLLGVFQKLIASKANDHQGFYL LNSIIEHMPPESVDQYRKQI FILLFQRLQNSKTTKFIKSFLVFIN LYCIKYGALALQEIFDGIQPKMFGM VLEKIIIPEIQKVSGNVEKK ICAVGITKLLTECPPMMDTEYTKLW TPLLQSLIGLFELPEDDTIPDEEHF IDIEDTPGYQTAFSQLAFAG
  KKEHDPVGQMVNNPKIHLAQSLHKL STACPGRVPSMVSTSLNAEALQYLQ GYLQAASVTLLTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: CSE1L chromosome segregation 1 like [ Homo sapiens (human) ]
• Official Symbol: CSE1L
• Synonyms: CAS; CSE1; XPO2
• Gene ID: 1434
• mRNA Refseq: NM_001316.4
• Protein Refseq: NP_001307.2
• MIM: 601342
• UniProt ID: P55060