Recombinant Full Length Human DCAF7 Protein, GST-tagged

• Cat.No.: DCAF7-3456HF
• Product Overview: Human HAN11 full-length ORF ( AAH01264, 1 a.a. - 342 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 63.14 kDa
• Protein Length: 342 amino acids
• AA Sequence: MSLHGKRKEIYKYEAPWTVYAMNWS VRPDKRFRLALGSFVEEYNNKVQLV GLDEESSEFICRNTFDHPYPTTKLM WIPDTKGVYPDLLATSGDYLRVWRV GETETRLECLLNNNKNSDFCAPLTS FDWNEVDPYLLGTSSIDTTCTIWGL ETGQVLGRVNLVSGHVKTQLIAHDK EVYDIAFSRAGGGRDMFASVGADGS VRMFDLRHLEHSTIIYEDPQHHPLL RLCWNKQDPNYLATMAMDGMEVVIL DVRVPCTPVARLNNHRACVNGIAWA PHSSCHICTAADDHQALIWDIQQMP RAIEDPILAYTAEGEINNVQWASTQ PDWIAICYNNCLEILRV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DCAF7 DDB1 and CUL4 associated factor 7 [ Homo sapiens (human) ]
• Official Symbol: DCAF7
• Synonyms: DCAF7; DDB1 and CUL4 associated factor 7; AN11; HAN11; WDR68; SWAN-1; DDB1- and CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog; human anthocyanin; seven-WD-repeat protein of the AN11 family-1
• Gene ID: 10238
• mRNA Refseq: NM_005828
• Protein Refseq: NP_005819
• MIM: 605973
• UniProt ID: P61962

Reviews

09/06/2020

The DCAF7 protein is a top-quality product that is sure to fulfill my experimental requirements.

05/02/2019

It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

11/02/2016

the ease of use and compatibility of the DCAF7 protein with various techniques further enhances its appeal.

Q&As

How does DCAF7 protein contribute to the development of drug resistance in cancer?

DCAF7 protein has been implicated in promoting drug resistance in cancer cells by affecting DNA repair pathways, making it an important factor in cancer treatment resistance.

Are there any known genetic alterations in the DCAF7 gene associated with cancer susceptibility?

While specific genetic alterations in the DCAF7 gene have not been extensively studied, it is possible that mutations or dysregulation of the gene may contribute to cancer susceptibility.

Is there any evidence linking DCAF7 protein to specific types of cancer?

Research has suggested that DCAF7 protein may be involved in the development of various types of cancer, including breast, ovarian, and colorectal cancer.

How is the expression of DCAF7 protein assessed in clinical settings?

The expression of DCAF7 protein can be assessed using immunohistochemistry or molecular techniques, which may provide valuable information for cancer prognosis and treatment planning.

Can targeting DCAF7 protein have potential implications for personalized cancer therapy?

Targeting DCAF7 protein may have implications for personalized cancer therapy by exploiting specific vulnerabilities in cancer cells related to DNA repair mechanisms.