Recombinant Full Length Human DDB1 Protein, GST-tagged
Cat.No. : | DDB1-6896HF |
Product Overview : | Recombinant Human full-length DDB1(1 a.a. - 1140 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ. |
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Description : | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Form : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Molecular Mass : | 153.4 kDa |
Protein Length : | 1140 amino acids |
AA Sequence : | MSYNYVVTAQKPTAVNGCVTGHFTS AEDLNLLIAKNTRLEIYVVTAEGLR PVKEVGMYGKIAVMELFRPKGESKD LLFILTAKYNACILEYKQSGESIDI ITRAHGNVQDRIGRPSETGIIGIID PECRMIGLRLYDGLFKVIPLDRDNK ELKAFNIRLEELHVIDVKFLYGCQA PTICFVYQDPQGRHVKTYEVSLREK EFNKGPWKQENVEAEASMVIAVPEP FGGAIIIGQESITYHNGDKYLAIAP PIIKQSTIVCHNRVDPNGSRYLLGD MEGRLFMLLLEKEEQMDGTVTLKDL RVELLGETSIAECLTYLDNGVVFVG SRLGDSQLVKLNVDSNEQGSYVVAM ETFTNLGPIVDMCVVDLERQGQGQL VTCSGAFKEGSLRIIRNGIGIHEHA SIDLPGIKGLWPLRSDPNRETDDTL VLSFVGQTRVLMLNGEEVEETELMG FVDDQQTFFCGNVAHQQLIQITSAS VRLVSQEPKALVSEWKEPQAKNISV ASCNSSQVVVAVGRALYYLQIHPQE LRQISHTEMEHEVACLDITPLGDSN GLSPLCAIGLWTDISARILKLPSFE LLHKEMLGGEIIPRSILMTTFESSH YLLCALGDGALFYFGLNIETGLLSD RKKVTLGTQPTVLRTFRSLSTTNVF ACSDRPTVIYSSNHKLVFSNVNLKE VNYMCPLNSDGYPDSLALANNSTLT IGTIDEIQKLHIRTVPLYESPRKIC YQEVSQCFGVLSSRIEVQDTSGGTT ALRPSASTQALSSSVSSSKLFSSST APHETSFGEEVEVHNLLIIDQHTFE VLHAHQFLQNEYALSLVSCKLGKDP NTYFIVGTAMVYPEEAEPKQGRIVV FQYSDGKLQTVAEKEVKGAVYSMVE FNGKLLASINSTVRLYEWTTEKELR TECNHYNNIMALYLKTKGDFILVGD LMRSVLLLAYKPMEGNFEEIARDFN PNWMSAVEILDDDNFLGAENAFNLF VCQKDSAATTDEERQHLQEVGLFHL GEFVNVFCHGSLVMQNLGETSTPTQ GSVLFGTVNGMIGLVTSLSESWYNL LLDMQNRLNKVIKSVGKIEHSFWRS FHTERKTEPATGFIDGDLIESFLDI SRPKMQEVVANLQYDDGSGMKREAT ADDLIKVVEELTRIH |
Applications : | Enzyme-linked Immunoabsorbent; Assay Western Blot (Recombinant protein); Antibody Production; Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | DDB1 damage specific DNA binding protein 1 [ Homo sapiens (human) ] |
Official Symbol : | DDB1 |
Synonyms : | DDB1; damage-specific DNA binding protein 1, 127kDa; damage specific DNA binding protein 1 (127kD); DNA damage-binding protein 1; XPE; XAP-1; UV-DDB 1; DDB p127 subunit; XPE-binding factor; HBV X-associated protein 1; DNA damage-binding protein a; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; damage-specific DNA-binding protein 1; xeroderma pigmentosum group E-complementing protein; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; |
Gene ID : | 1642 |
mRNA Refseq : | NM_001923 |
Protein Refseq : | NP_001914 |
MIM : | 600045 |
UniProt ID : | Q16531 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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