Recombinant Full Length Human DNMT3B Protein, GST-tagged
Cat.No. : | DNMT3B-4052HF |
Product Overview : | Human DNMT3B full-length ORF (NP_787045.1, 1 a.a. - 770 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
- Download
Description : | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 112.6 kDa |
Protein Length : | 770 amino acids |
AA Sequence : | MKGDTRHLNGEEDAGGREDSILVNG ACSDQSSDSPPILEAIRTPEIRGRR SSSRLSKREVSSLLSYTQDLTGDGD GEDGDGSDTPVMPKLFRETRTRSES PAVRTRNNNSVSSRERHRPSPRSTR GRQGRNHVDESPVEFPATRSLRRRA TASAGTPWPSPPSSYLTIDLTDDTE DTHGTPQSSSTPYARLAQDSQQGGM ESPQVEADRGDGDSSEYQDGKEFGI GDLVWGKIKGFSWWPAMVVSWKATS KRQAMSGMRWVQWFGDGKFSEVSAD KLVALGLFSQHFNLATFNKLVSYRK AMYHALEKARVRAGKTFPSSPGDSL EDQLKPMLEWAHGGFKPTGIEGLKP NNTQPENKTRRRTADDSATSDYCPA PKHLKTNCYNNGKDRGDEDQSREQM ASDVANNKSSLEDGCLSCGRKNPVS FHPLFEGGLCQTCRDRFLELFYMYD DDGYQSYCTVCCEGRELLLCSNTSC CRCFCVECLEVLVGTGTAAEAKLQE PWSCYMCLPQRCHGVLRRRKDWNVR LQAFFTSDTGLEYEAPKLYPAIPAA RRRPIRVLSLFDGIATGYLVLKELG IKVGKYVASEVCEESIAVGTVKHEG NIKYVNDVRNITKKNIEEWGPFDLV IGGSPCNDLSNVNPARKGLYEGTGR LFFEFYHLLNYSRPKEGDDRPFFWM FENVVAMKVGDKRDISRFLECNPVM IDAIKVSAAHRARYFWGNLPGMNRI FGFPVHYTDVSNMGRGARQKLLGRS WSVPVIRHLFAPLKDYFACE |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta [ Homo sapiens ] |
Official Symbol : | DNMT3B |
Synonyms : | DNMT3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5)-methyltransferase 3B; DNA MTase HsaIIIB; DNA methyltransferase HsaIIIB; ICF; ICF1; M.HsaIIIB; |
Gene ID : | 1789 |
mRNA Refseq : | NM_001207055 |
Protein Refseq : | NP_001193984 |
MIM : | 602900 |
UniProt ID : | Q9UBC3 |
Products Types
◆ Recombinant Protein | ||
DNMT3B-780H | Recombinant Human DNMT3B Protein, His (Fc)-Avi-tagged | +Inquiry |
DNMT3B-895H | Recombinant Human DNMT3B Protein, His-tagged | +Inquiry |
Dnmt3b-2622M | Recombinant Mouse Dnmt3b Protein, Myc/DDK-tagged | +Inquiry |
DNMT3B-2792H | Recombinant Human DNMT3B Protein, GST-tagged | +Inquiry |
DNMT3B-1360H | Recombinant Human DNMT3B Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
DNMT3B-6854HCL | Recombinant Human DNMT3B 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1716 | DNMT3B Chemiluminescent Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionTargeting DNMT3B for therapeutic purposes may lead to off-target effects and unintended changes in DNA methylation, potentially causing adverse effects on normal cellular function and gene expression.
Yes, mutations in the DNMT3B gene are linked to a rare genetic disorder called ICF (Immunodeficiency, Centromeric instability, Facial anomalies) syndrome, characterized by immune system deficiencies, facial abnormalities, and unstable centromeric regions in chromosomes.
Research has shown that alterations in DNMT3B expression or activity can be associated with various types of cancer, making it a potential biomarker for cancer diagnosis, prognosis, and treatment response.
DNMT3B plays a crucial role in establishing de novo DNA methylation patterns during embryonic development and cell differentiation, contributing to the epigenetic regulation of gene expression.
Inhibition of DNMT3B activity through targeted therapy or epigenetic modifying agents has been explored as a potential treatment strategy to reverse abnormal DNA methylation patterns and restore normal gene expression in cancer cells.
Customer Reviews (3)
Write a reviewThe DNMT3B protein is of exceptional quality and has proven to be an ideal choice to meet my experimental requirements.
With its consistent and outstanding results, the DNMT3B protein is an indispensable tool that I highly recommend for researchers in need of reliable and precise protein analysis.
Its purity and reliability have consistently resulted in successful outcomes in my research projects, providing me with accurate and reproducible data.
Ask a Question for All DNMT3B Products
Required fields are marked with *
My Review for All DNMT3B Products
Required fields are marked with *
Inquiry Basket