Recombinant Full Length Human DRD1 Protein

• Cat.No.: DRD1-6909HF
• Product Overview: Recombinant Human full-length DRD1, fused without tag, was expressed in wheat germ.

Specification

• Description: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 49.3 kDa
• Protein Length: 446 amino acids
• AA Sequence: MRTLNTSAMDGTGLVVERDFSVRIL TACFLSLLILSTLLGNTLVCAAVIR FRHLRSKVTNFFVISLAVSDLLVAV LVMPWKAVAEIAGFWPFGSFCNIWV AFDIMCSTASILNLCVISVDRYWAI SSPFRYERKMTPKAAFILISVAWTL SVLISFIPVQLSWHKAKPTSPSDGN ATSLAETIDNCDSSLSRTYAISSSV ISFYIPVAIMIVTYTRIYRIAQKQI RRIAALERAAVHAKNCQTTTGNGKP VECSQPESSFKMSFKRETKVLKTLS VIMGVFVCCWLPFFILNCILPFCGS GETQPFCIDSNTFDVFVWFGWANSS LNPIIYAFNADFRKAFSTLLGCYRL CPATNNAIETVSINNNGAAMFSSHH EPRGSISKECNLVYLIPHAVGSSED LKKEEAAGIARPLEKLSPALSVILD YDTDVSLEKIQPITQNGQHPT
• Applications: Antibody Production; Functional Study; Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: DRD1 dopamine receptor D1 [ Homo sapiens (human) ]
• Official Symbol: DRD1
• Synonyms: DRD1; dopamine receptor D1; DADR; DRD1A; D(1A) dopamine receptor; dopamine D1 receptor
• Gene ID: 1812
• mRNA Refseq: NM_000794
• Protein Refseq: NP_000785
• MIM: 126449
• UniProt ID: P21728

Reviews

07/24/2022

Reliable data for insights. Supports our research.

09/06/2021

Precise and timely. Integral to our experiments.

03/22/2020

Boosts research efficiency. Trusted for accurate results.

Q&As

How do genetic variations in DRD1 affect its function?

Genetic mutations in DRD1 can alter dopamine signaling and brain function.

What role does DRD1 play in psychiatric disorders?

DRD1 is involved in various psychiatric and neurological disorders.

How does DRD1 contribute to cognitive processes?

It significantly modulates cognitive abilities and behavior.

What is the primary role of DRD1 in neurotransmission?

DRD1 is crucial for dopamine-mediated neurotransmission, influencing brain function.

What potential therapeutic applications arise from targeting DRD1?

Targeting DRD1 offers therapeutic potential for neurological and psychiatric conditions.

How does DRD1 interact with other dopamine receptors in the brain?

DRD1 works with other dopamine receptors, contributing to neural networks.

What is the impact of altered DRD1 activity on dopamine signaling?

Changes in DRD1 activity disrupt normal dopamine signaling, affecting mental health.