Recombinant Full Length Human DRD2 Protein

• Cat.No.: DRD2-6910HF
• Product Overview: Recombinant Human full-length DRD2, fused without tag, was expressed in wheat germ.

Specification

• Description: This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 48.73 kDa
• Protein Length: 443 amino acids
• AA Sequence: MDPLNLSWYDDDLERQNWSRPFNGS DGKADRPHYNYYATLLTLLIAVIVF GNVLVCMAVSREKALQTTTNYLIVS LAVADLLVATLVMPWVVYLEVVGEW KFSRIHCDIFVTLDVMMCTASILNL CAISIDRYTAVAMPMLYNTRYSSKR RVTVMISIVWVLSFTISCPLLFGLN NADQNECIIANPAFVVYSSIVSFYV PFIVTLLVYIKIYIVLRRRRKRVNT KRSSRAFRAHLRAPLKGNCTHPEDM KLCTVIMKSNGSFPVNRRRVEAARR AQELEMEMLSSTSPPERTRYSPIPP SHHQLTLPDPSHHGLHSTPDSPAKP EKNGHAKDHPKIAKIFEIQTMPNGK TRTSLKTMSRRKLSQQKEKKATQML AIVLGVFIICWLPFFITHILNIHCD CNIPPVLYSAFTWLGYVNSAVNPII YTTFNIEFRKAFLKILHC
• Applications: Antibody Production; Functional Study; Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: DRD2 dopamine receptor D2 [ Homo sapiens (human) ]
• Official Symbol: DRD2
• Synonyms: DRD2; dopamine receptor D2; D2R; D2DR; D(2) dopamine receptor; dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor
• Gene ID: 1813
• mRNA Refseq: NM_000795
• Protein Refseq: NP_000786
• MIM: 126450
• UniProt ID: P14416

Reviews

01/10/2019

Integral to our research success, highly recommended.

03/26/2018

Efficiency at its best, a research cornerstone.

03/26/2018

Swift and accurate service, accelerates research timelines.

Q&As

What potential therapeutic applications arise from targeting DRD2 in neurological disorders?

Targeting DRD2 could treat disorders like Parkinson's and schizophrenia.

How do genetic variations in DRD2 affect behavior?

Genetic variations in DRD2 influence behavioral and mental health responses.

How does DRD2 contribute to motor control?

It regulates motor control via dopamine pathways.

How does DRD2 interact with other dopamine receptors?

DRD2 collaborates with other dopamine receptors in brain functions.

What is the primary role of DRD2 in neurotransmission?

DRD2 modulates neurotransmitter signaling in the brain.

What role does DRD2 play in psychiatric disorders?

DRD2 is key in psychiatric conditions, affecting mood and cognition.

What is the impact of altered DRD2 activity on addiction?

Altered DRD2 activity is linked to addiction, affecting reward mechanisms.