Recombinant Full Length Human ESR1 Protein, GST-tagged
Cat.No. : | ESR1-4720HF |
Product Overview : | Human ESR1 full-length ORF ( AAI28574.1, 1 a.a. - 595 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 92.6 kDa |
Protein Length : | 595 amino acids |
AA Sequence : | MTMTLHTKASGMALLHQIQGNELEP LNRPQLKIPLERPLGEVYLDSSKPA VYNYPEGAAYEFNAAAAANAQVYGQ TGLPYGPGSEAAAFGSNGLGGFPPL NSVSPSPLMLLHPPPQLSPFLQPHG QQVPYYLENEPSGYTVREAGPPAFY RPNSDNRRQGGRERLASTNDKGSMA MESAKETRYCAVCNDYASGYHYGVW SCEGCKAFFKRSIQGHNDYMCPATN QCTIDKNRRKSCQACRLRKCYEVGM MKGGIRKDRRGGRMLKHKRQRDDGE GRGEVGSAGDMRAANLWPSPLMIKR SKKNSLALSLTADQMVSALLDAEPP ILYSEYDPTRPFSEASMMGLLTNLA DRELVHMINWAKRVPGFVDLTLHDQ VHLLECAWLEILMIGLVWRSMEHPG KLLFAPNLLLDRNQGKCVEGMVEIF DMLLATSSRFRMMNLQGEEFVCLKS IILLNSGVYTFLSSTLKSLEEKDHI HRVLDKITDTLIHLMAKAGLTLQQQ HQRLAQLLLILSHIRHMSNKGMEHL YSMKCKNVVPLYDLLLEMLDAHRLH APTSRGGASVEETDQSHLATAGSTS SHSLQKYYITGEAEGFPATV |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ESR1 estrogen receptor 1 [ Homo sapiens ] |
Official Symbol : | ESR1 |
Synonyms : | ESR1; estrogen receptor 1; ESR; estrogen receptor; Era; NR3A1; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha delta 4 +49 isoform; nuclear receptor subfamily 3 group A member 1; estrogen receptor alpha 3*,4,5,6,7*/822 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform; ER; ESRA; DKFZp686N23123; |
Gene ID : | 2099 |
mRNA Refseq : | NM_000125 |
Protein Refseq : | NP_000116 |
MIM : | 133430 |
UniProt ID : | P03372 |
Products Types
◆ Recombinant Protein | ||
Esr1-977M | Recombinant Mouse Esr1 Protein, MYC/DDK-tagged | +Inquiry |
ESR1-1390H | Recombinant Human ESR1 Protein (10-595 aa), His-tagged | +Inquiry |
ESR1-868H | Recombinant Human ESR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ESR1-3504H | Recombinant Human ESR1 Protein, GST-tagged | +Inquiry |
ESR1-02H | Recombinant Human ESR1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ESR1-6540HCL | Recombinant Human ESR1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionESR1 mutations can lead to resistance to endocrine therapies in breast cancer patients, impacting treatment outcomes.
ESR1 testing can provide important prognostic information by helping to predict the likelihood of a favorable response to hormone therapy.
ESR1 protein can be detected through various laboratory techniques, including immunohistochemistry (IHC) and immunoblotting.
Research is ongoing, and there are efforts to develop targeted therapies for ESR1-mutated breast cancer, but it's still an evolving field.
ESR1 status is determined through the examination of tumor tissue samples, often using IHC or molecular testing.
Customer Reviews (3)
Write a reviewIts high specificity and robust activity make it an ideal candidate for investigating intricate molecular interactions and elucidating complex biological mechanisms.
Tthe manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed. he manufacturer's commitment to exceptional technical support offers me peace of mind, knowing that any challenges or concerns I may encounter will be effectively addressed.
With the ESR1 protein, I can confidently pursue my scientific objectives and overcome experimental obstacles, enabling me to make significant strides in my field of study.
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