Recombinant Full Length Human F13A1 Protein, C-Flag-tagged
Cat.No. : | F13A1-1437HFL |
Product Overview : | Recombinant Full Length Human F13A1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 79.2 kDa |
AA Sequence : | MSETSRTAFGGRRAVPPNNSNAAED DLPTVELQGVVPRGVNLQEFLNVTS VHLFKERWDTNKVDHHTDKY ENNKLIVRRGQSFYVQIDFSRPYDP RRDLFRVEYVIGRYPQENKGTYIPV PIVSELQSGKWGAKIVMRED RSVRLSIQSSPKCIVGKFRMYVAVW TPYGVLRTSRNPETDTYILFNPWCE DDAVYLDNEKEREEYVLNDI GVIFYGEVNDIKTRSWSYGQFEDGI LDTCLYVMDRAQMDLSGRGNPIKVS RVGSAMVNAKDDEGVLVGSW DNIYAYGVPPSAWTGSVDILLEYRS SENPVRYGQCWVFAGVFNTFLRCLG IPARIVTNYFSAHDNDANLQ MDIFLEEDGNVNSKLTKDSVWNYHC WNEAWMTRPDLPVGFGGWQAVDSTP QENSDGMYRCGPASVQAIKH GHVCFQFDAPFVFAEVNSDLIYITA KKDGTHVVENVDATHIGKLIVTKQI GGDGMMDITDTYKFQEGQEE ERLALETALMYGAKKPLNTEGVMKS RSNVDMDFEVENAVLGKDFKLSITF RNNSHNRYTITAYLSANITF YTGVPKAEFKKETFDVTLEPLSFKK EAVLIQAGEYMGQLLEQASLHFFVT ARINETRDVLAKQKSTVLTI PEIIIKVRGTQVVGSDMTVIVEFTN PLKETLRNVWVHLDGPGVTRPMKKM FREIRPNSTVQWEEVCRPWV SGHRKLIASMSSDSLRHVYGELDVQ IQRRPSMTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Secreted Protein |
Protein Pathways : | Complement and coagulation cascades |
Gene Name : | F13A1 coagulation factor XIII A chain [ Homo sapiens (human) ] |
Official Symbol : | F13A1 |
Synonyms : | F13A |
Gene ID : | 2162 |
mRNA Refseq : | NM_000129.4 |
Protein Refseq : | NP_000120.2 |
MIM : | 134570 |
UniProt ID : | P00488 |
Products Types
◆ Recombinant Protein | ||
F13A1-2497H | Recombinant Human F13A1 protein(431-520 aa), C-His-tagged | +Inquiry |
F13A1-1332H | Recombinant Human F13A1 Protein, His-tagged | +Inquiry |
F13A1-3609H | Recombinant Human F13A1 Protein, GST-tagged | +Inquiry |
F13a1-2900M | Recombinant Mouse F13a1 Protein, Myc/DDK-tagged | +Inquiry |
F13A1-881H | Recombinant Human F13A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F13A1-5399H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
F13A1-28806TH | Native Human F13A1 | +Inquiry |
F13A1-1881H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
◆ Lysates | ||
F13A1-6485HCL | Recombinant Human F13A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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