Recombinant Full Length Human FAP Protein, C-Flag-tagged

• Cat.No.: FAP-589HFL
• Product Overview: Recombinant Full Length Human FAP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 87.5 kDa
• AA Sequence: MKTWVKIVFGVATSAVLALLVMCIV LRPSRVHNSEENTMRALTLKDILNG TFSYKTFFPNWISGQEYLHQ SADNNIVLYNIETGQSYTILSNRTM KSVNASNYGLSPDRQFVYLESDYSK LWRYSYTATYYIYDLSNGEF VRGNELPRPIQYLCWSPVGSKLAYV YQNNIYLKQRPGDPPFQITFNGREN KIFNGIPDWVYEEEMLATKY ALWWSPNGKFLAYAEFNDTDIPVIA YSYYGDEQYPRTINIPYPKAGAKNP VVRIFIIDTTYPAYVGPQEV PVPAMIASSDYYFSWLTWVTDERVC LQWLKRVQNVSVLSICDFREDWQTW DCPKTQEHIEESRTGWAGGF FVSTPVFSYDAISYYKIFSDKDGYK HIHYIKDTVENAIQITSGKWEAINI FRVTQDSLFYSSNEFEEYPG RRNIYRISIGSYPPSKKCVTCHLRK ERCQYYTASFSDYAKYYALVCYGPG IPISTLHDGRTDQEIKILEE NKELENALKNIQLPKEEIKKLEVDE ITLWYKMILPPQFDRSKKYPLLIQV YGGPCSQSVRSVFAVNWISY LASKEGMVIALVDGRGTAFQGDKLL YAVYRKLGVYEVEDQITAVRKFIEM GFIDEKRIAIWGWSYGGYVS SLALASGTGLFKCGIAVAPVSSWEY YASVYTERFMGLPTKDDNLEHYKNS TVMARAEYFRNVDYLLIHGT
  ADDNVHFQNSAQIAKALVNAQVDFQ AMWYSDQNHGLSGLSTNHLYTHMTH FLKQCFSLSDSGPTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Transmembrane

Gene Information

• Gene Name: FAP fibroblast activation protein alpha [ Homo sapiens (human) ]
• Official Symbol: FAP
• Synonyms: FAPA; SIMP; DPPIV; FAPalpha
• Gene ID: 2191
• mRNA Refseq: NM_004460.5
• Protein Refseq: NP_004451.2
• MIM: 600403
• UniProt ID: Q12884