| Description : |
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
49.210kDa inclusive of tags |
| Protein Length : |
210 amino acids |
| AA Sequence : |
MNILEKVVLKVLEDQQNIRLIRELL QTLYTSLCTLVQRVGKSVLVGNINM WVYRMETILHWQQQLNNIQITRPAF KGLTFTDLPLCLQLNIMQRLSDGRD LVSLGQAAPDLHVLSEDRLLWKKLC QYHFSERQIRKRLILSGKGQLDWKK MYFKLVRCYPRKEQYGDTLQLRKHC HILSWKGTDHPCTANNPESCSVSLS PQDFINLFKF |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
