Recombinant Full Length Human FCGR2B Protein, C-Flag-tagged

• Cat.No.: FCGR2B-1077HFL
• Product Overview: Recombinant Full Length Human FCGR2B Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 33.8 kDa
• AA Sequence: MGILSFLPVLATESDWADCKSPQPW GHMLLWTAVLFLAPVAGTPAAPPKA VLKLEPQWINVLQEDSVTLT CRGTHSPESDSIQWFHNGNLIPTHT QPSYRFKANNNDSGEYTCQTGQTSL SDPVHLTVLSEWLVLQTPHP EFQEGETIVLRCHSWKDKPLVKVTF FQNGKSKKFSRSDPNFSIPQANHSH SGDYHCTGNIGYTLYSSKPV TITVQAPSSSPMGIIVAVVTGIAVA AIVAAVVALIYCRKKRISALPGYPE CREMGETLPEKPANPTNPDE
  ADKVGAENTITYSLLMHPDALEEPD DQNRITRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: B cell receptor signaling pathway, Fc gamma R-mediated phagocytosis, Systemic lupus erythematosus

Gene Information

• Gene Name: FCGR2B Fc gamma receptor IIb [ Homo sapiens (human) ]
• Official Symbol: FCGR2B
• Synonyms: CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb
• Gene ID: 2213
• mRNA Refseq: NM_001002275.3
• Protein Refseq: NP_001002275.1
• MIM: 604590
• UniProt ID: P31994