Recombinant Full Length Human FCGR3A Protein, C-Flag-tagged

• Cat.No.: FCGR3A-138HFL
• Product Overview: Recombinant Full Length Human FCGR3A Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 27.2 kDa
• AA Sequence: MGGGAGERLFTSSCLVGLVPLGLRI SLVTCPLQCGIMWQLLLPTALLLLV SAGMRTEDLPKAVVFLEPQW YRVLEKDSVTLKCQGAYSPEDNSTQ WFHNESLISSQASSYFIDAATVDDS GEYRCQTNLSTLSDPVQLEV HIGWLLLQAPRWVFKEEDPIHLRCH SWKNTALHKVTYLQNGKGRKYFHHN SDFYIPKATLKDSGSYFCRG LVGSKNVSSETVNITITQGLAVSTI SSFFPPGYQVSFCLVMVLLFAVDTG LYFSVKTNIRSSTRDWKDHK
  FKWRKDPQDKTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
• Protein Pathways: Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus

Gene Information

• Gene Name: FCGR3A Fc gamma receptor IIIa [ Homo sapiens (human) ]
• Official Symbol: FCGR3A
• Synonyms: CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA
• Gene ID: 2214
• mRNA Refseq: NM_000569.8
• Protein Refseq: NP_000560.7
• MIM: 146740
• UniProt ID: P08637