Recombinant Full Length Human FKRP Protein, C-Flag-tagged

• Cat.No.: FKRP-432HFL
• Product Overview: Recombinant Full Length Human FKRP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein which is targeted to the medial Golgi apparatus and is necessary for posttranslational modification of dystroglycan. Mutations in this gene have been associated with congenital muscular dystrophy, cognitive disability, and cerebellar cysts. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 54.4 kDa
• AA Sequence: MRLTRCQAALAAAITLNLLVLFYVS WLQHQPRNSRARGPRRASAAGPRVT VLVREFEAFDNAVPELVDSF LQQDPAQPVVVAADTLPYPPLALPR IPNVRLALLQPALDRPAAASRPETY VATEFVALVPDGARAEAPGL LERMVEALRAGSARLVAAPVATANP ARCLALNVSLREWTARYGAAPAAPR CDALDGDAVVLLRARDLFNL SAPLARPVGTSLFLQTALRGWAVQL LDLTFAAARQPPLATAHARWKAERE GRARRAALLRALGIRLVSWE GGRLEWFGCNKETTRCFGTVVGDTP AYLYEERWTPPCCLRALRETARYVV GVLEAAGVRYWLEGGSLLGA ARHGDIIPWDYDVDLGIYLEDVGNC EQLRGAEAGSVVDERGFVWEKAVEG DFFRVQYSESNHLHVDLWPF YPRNGVMTKDTWLDHRQDVEFPEHF LQPLVPLPFAGFVAQAPNNYRRFLE LKFGPGVIENPQYPNPALLS
  LTGSGTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane

Gene Information

• Gene Name: FKRP fukutin related protein [ Homo sapiens (human) ]
• Official Symbol: FKRP
• Synonyms: FKTR; MDC1C; LGMD2I; LGMDR9; MDDGA5; MDDGB5; MDDGC5
• Gene ID: 79147
• mRNA Refseq: NM_024301.5
• Protein Refseq: NP_077277.1
• MIM: 606596
• UniProt ID: Q9H9S5