Recombinant Full Length Human FLT1 Protein, C-Flag-tagged

• Cat.No.: FLT1-1576HFL
• Product Overview: Recombinant Full Length Human FLT1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 148 kDa
• AA Sequence: MVSYWDTGVLLCALLSCLLLTGSSS GSKLKDPELSLKGTQHIMQAGQTLH LQCRGEAAHKWSLPEMVSKE SERLSITKSACGRNGKQFCSTLTLN TAQANHTGFYSCKYLAVPTSKKKET ESAIYIFISDTGRPFVEMYS EIPEIIHMTEGRELVIPCRVTSPNI TVTLKKFPLDTLIPDGKRIIWDSRK GFIISNATYKEIGLLTCEAT VNGHLYKTNYLTHRQTNTIIDVQIS TPRPVKLLRGHTLVLNCTATTPLNT RVQMTWSYPDEKNKRASVRR RIDQSNSHANIFYSVLTIDKMQNKD KGLYTCRVRSGPSFKSVNTSVHIYD KAFITVKHRKQQVLETVAGK RSYRLSMKVKAFPSPEVVWLKDGLP ATEKSARYLTRGYSLIIKDVTEEDA GNYTILLSIKQSNVFKNLTA TLIVNVKPQIYEKAVSSFPDPALYP LGSRQILTCTAYGIPQPTIKWFWHP CNHNHSEARCDFCSNNEESF ILDADSNMGNRIESITQRMAIIEGK NKMASTLVVADSRISGIYICIASNK VGTVGRNISFYITDVPNGFH VNLEKMPTEGEDLKLSCTVNKFLYR DVTWILLRTVNNRTMHYSISKQKMA ITKEHSITLNLTIMNVSLQD SGTYACRARNVYTGEEILQKKEITI RDQEAPYLLRNLSDHTVAISSSTTL DCHANGVPEPQITWFKNNHK IQQEPGIILGPGSSTLFIERVTEED EGVYHCKATNQKGSVESSAYLTVQG TSDKSNLELITLTCTCVAAT LFWLLLTLFIRKMKRSSSEIKTDYL SIIMDPDEVPLDEQCERLPYDASKW EFARERLKLGKSLGRGAFGK VVQASAFGIKKSPTCRTVAVKMLKE GATASEYKALMTELKILTHIGHHLN VVNLLGACTKQGGPLMVIVE YCKYGNLSNYLKSKRDLFFLNKDAA LHMEPKKEKMEPGLEQGKKPRLDSV TSSESFASSGFQEDKSLSDV EEEEDSDGFYKEPITMEDLISYSFQ VARGMEFLSSRKCIHRDLAARNILL SENNVVKICDFGLARDIYKN PDYVRKGDTRLPLKWMAPESIFDKI YSTKSDVWSYGVLLWEIFSLGGSPY PGVQMDEDFCSRLREGMRMR APEYSTPEIYQIMLDCWHRDPKERP RFAELVEKLGDLLQANVQQDGKDYI PINAILTGNSGFTYSTPAFS EDFFKESISAPKFNSGSSDDVRYVN AFKFMSLERIKTFEELLPNATSMFD DYQGDSSTLLASPMLKRFTW TDSKPKASLKIDLRVTSKSKESGLS DVSRPSFCHSSCGHVSEGKRRFTYD HAELERKIACCSPPPDYNSV
  VLYSTPPITRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion

Gene Information

• Gene Name: FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: FLT1
• Synonyms: FLT; FLT-1; VEGFR1; VEGFR-1
• Gene ID: 2321
• mRNA Refseq: NM_002019.4
• Protein Refseq: NP_002010.2
• MIM: 165070
• UniProt ID: P17948