Recombinant Full Length Human FOXP3 Protein, GST-tagged
Cat.No. : | FOXP3-6933HF |
Product Overview : | Recombinant Human full-length FOXP3 (1 a.a. - 431 a.a.) fused with GST-tag at N-terminal, was expressed in wheat germ. |
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Description : | The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 73.6 kDa |
Protein Length : | 431 amino acids |
Applications : | ELISA; WB |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | FOXP3 forkhead box P3 [ Homo sapiens ] |
Official Symbol : | FOXP3 |
Synonyms : | FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked |
Gene ID : | 50943 |
mRNA Refseq : | NM_014009 |
Protein Refseq : | NP_054728 |
MIM : | 300292 |
UniProt ID : | Q9BZS1 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, elevated or decreased levels of FOXP3 expression can serve as a biomarker for various diseases, including autoimmune conditions and certain cancers.
Yes, the expression of FOXP3 in tumor-infiltrating lymphocytes is studied as a potential prognostic marker in various cancers, with higher levels often associated with a better prognosis.
FOXP3 is crucial for immune tolerance in transplant recipients. Enhancing Treg function, possibly through manipulating FOXP3, is a focus for transplant research to prevent rejection.
FOXP3 is studied in cancer to understand its role in suppressing anti-tumor immune responses. Manipulating Tregs or targeting FOXP3 may be explored for cancer immunotherapy.
FOXP3 helps regulate immune responses, including those involved in allergies. Dysfunction in FOXP3 or Tregs may contribute to allergic disorders.
Customer Reviews (3)
Write a reviewIts purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.
The FOXP3 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.
The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.
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