Recombinant Full Length Human GBA2 Protein, C-Flag-tagged

• Cat.No.: GBA2-855HFL
• Product Overview: Recombinant Full Length Human GBA2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 104.5 kDa
• AA Sequence: MGTQDPGNMGTGVPASEQISCAKED PQVYCPEETGGTKDVQVTDCKSPED SRPPKETDCCNPEDSGQLMV SYEGKAMGYQVPPFGWRICLAHEFT EKRKPFQANNVSLSNMIKHIGMGLR YLQWWYRKTHVEKKTPFIDM INSVPLRQIYGCPLGGIGGGTITRG WRGQFCRWQLNPGMYQHRTVIADQF TVCLRREGQTVYQQVLSLER PSVLRSWNWGLCGYFAFYHALYPRA WTVYQLPGQNVTLTCRQITPILPHD YQDSSLPVGVFVWDVENEGD EALDVSIMFSMRNGLGGGDDAPGGL WNEPFCLERSGETVRGLLLHHPTLP NPYTMAVAARVTAATTVTHI TAFDPDSTGQQVWQDLLQDGQLDSP TGQSTPTQKGVGIAGAVCVSSKLRP RGQCRLEFSLAWDMPRIMFG AKGQVHYRRYTRFFGQDGDAAPALS HYALCRYAEWEERISAWQSPVLDDR SLPAWYKSALFNELYFLADG GTVWLEVLEDSLPEELGRNMCHLRP TLRDYGRFGYLEGQEYRMYNTYDVH FYASFALIMLWPKLELSLQY DMALATLREDLTRRRYLMSGVMAPV KRRNVIPHDIGDPDDEPWLRVNAYL IHDTADWKDLNLKFVLQVYR DYYLTGDQNFLKDMWPVCLAVMESE MKFDKDHDGLIENGGYADQTYDGWV TTGPSAYCGGLWLAAVAVMV QMAALCGAQDIQDKFSSILSRGQEA YERLLWNGRYYNYDSSSRPQSRSVM SDQCAGQWFLKACGLGEGDT EVFPTQHVVRALQTIFELNVQAFAG GAMGAVNGMQPHGVPDKSSVQSDEV WVGVVYGLAATMIQEGLTWE GFQTAEGCYRTVWERLGLAFQTPEA YCQQRVFRSLAYMRPLSIWAMQLAL QQQQHKKASWPKVKQGTGLR
  TGPMFGPKEAMANLSPETRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: GBA2 glucosylceramidase beta 2 [ Homo sapiens (human) ]
• Official Symbol: GBA2
• Synonyms: AD035; SPG46; NLGase
• Gene ID: 57704
• mRNA Refseq: NM_020944.3
• Protein Refseq: NP_065995.1
• MIM: 609471
• UniProt ID: Q9HCG7