Recombinant Full Length Human GNA11 Protein, C-Flag-tagged

• Cat.No.: GNA11-1479HFL
• Product Overview: Recombinant Full Length Human GNA11 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 41.9 kDa
• AA Sequence: MTLESMMACCLSDEVKESKRINAEI EKQLRRDKRDARRELKLLLLGTGES GKSTFIKQMRIIHGAGYSEE DKRGFTKLVYQNIFTAMQAMIRAME TLKILYKYEQNKANALLIREVDVEK VTTFEHQYVSAIKTLWEDPG IQECYDRRREYQLSDSAKYYLTDVD RIATLGYLPTQQDVLRVRVPTTGII EYPFDLENIIFRMVDVGGQR SERRKWIHCFENVTSIMFLVALSEY DQVLVESDNENRMEESKALFRTIIT YPWFQNSSVILFLNKKDLLE DKILYSHLVDYFPEFDGPQRDAQAA REFILKMFVDLNPDSDKIIYSHFTC ATDTENIRFVFAAVKDTILQ
  LNLKEYNLVTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Vascular smooth muscle contraction

Gene Information

• Gene Name: GNA11 G protein subunit alpha 11 [ Homo sapiens (human) ]
• Official Symbol: GNA11
• Synonyms: FBH; FBH2; FHH2; HG1K; HHC2; GNA-11; HYPOC2
• Gene ID: 2767
• mRNA Refseq: NM_002067.5
• Protein Refseq: NP_002058.2
• MIM: 139313
• UniProt ID: P29992