Recombinant Full Length Human GPNMB Protein, GST-tagged
Cat.No. : | GPNMB-5557HF |
Product Overview : | Human GPNMB full-length ORF ( AAH32783.1, 1 a.a. - 572 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 88.44 kDa |
Protein Length : | 572 amino acids |
AA Sequence : | MECLYYFLGFLLLAARLPLDAAKRF HDVLGNERPSAYMREHNQLNGWSSD ENDWNEKLYPVWKRGDMRWKNSWKG GRVQAVLTSDSPALVGSNITFAVNL IFPRCQKEDANGNIVYEKNCRNEAG LSADPYVYNWTAWSEDSDGENGTGQ SHHNVFPDGKPFPHHPGWRRWNFIY VFHTLGQYFQKLGRCSVRVSVNTAN VTLGPQLMEVTVYRRHGRAYVPIAQ VKDVYVVTDQIPVFVTMFQKNDRNS SDETFLKDLPIMFDVLIHDPSHFLN YSTINYKWSFGDNTGLFVSTNHTVN HTYVLNGTFSLNLTVKAAAPGPCPP PPPPPRPSKPTPSLATTLKSYDSNT PGPAGDNPLELSRIPDENCQINRYG HFQATITIVEGILEVNIIQMTDVLM PVPWPESSLIDFVVTCQGSIPTEVC TIISDPTCEITQNTVCSPVDVDEMC LLTVRRTFNGSGTYCVNLTLGDDTS LALTSTLISVPDRDPASPLRMANSA LISVGCLAIFVTVISLLVYKKHKEY NPIENSPGNVVRSKGLSVFLNRAKA VFFPGNQEKDPLLKNQEFKGVS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GPNMB glycoprotein (transmembrane) nmb [ Homo sapiens ] |
Official Symbol : | GPNMB |
Synonyms : | GPNMB; glycoprotein (transmembrane) nmb; transmembrane glycoprotein NMB; glycoprotein NMB; glycoprotein nmb like protein; HGFIN; NMB; osteoactivin; transmembrane glycoprotein; glycoprotein nmb-like protein; transmembrane glycoprotein HGFIN; |
Gene ID : | 10457 |
mRNA Refseq : | NM_001005340 |
Protein Refseq : | NP_001005340 |
MIM : | 604368 |
UniProt ID : | Q14956 |
Products Types
◆ Recombinant Protein | ||
GPNMB-82H | Recombinant Human GPNMB Protein, His (Fc)-Avi-tagged | +Inquiry |
GPNMB-402H | Recombinant Human GPNMB Protein, His-tagged | +Inquiry |
GPNMB-2238H | Recombinant Human GPNMB Protein, MYC/DDK-tagged | +Inquiry |
Gpnmb-3290M | Recombinant Mouse Gpnmb Protein, Myc/DDK-tagged | +Inquiry |
GPNMB-3782H | Recombinant Human GPNMB protein(Met1-Pro474), His-tagged | +Inquiry |
◆ Lysates | ||
GPNMB-1423MCL | Recombinant Mouse GPNMB cell lysate | +Inquiry |
GPNMB-1886HCL | Recombinant Human GPNMB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIn the experiment, the GPNMB gene can be introduced into the expression vector by gene cloning technology, and then the GPNMB recombinant protein can be expressed in Escherichia coli or eukaryotic cells.
Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role and disease mechanism of GPNMB recombinant protein in vivo. These animal models can be used to study the effects of GPNMB recombinant proteins on tumor growth, metastasis, and drug resistance.
The current treatments for GPNMB recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell surface receptors and signal transduction processes.
By detecting the expression level and modification status of GPNMB recombinant protein, it can be used to diagnose certain tumor diseases. In addition, the recombinant protein of GPNMB may also become a new target for the treatment of tumors, providing new ideas and methods for tumor treatment.
GPNMB recombinant protein can interact with other proteins, such as cell surface receptors such as integrin, and participate in cell signal transduction processes.
If the level of GPNMB recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.
Customer Reviews (3)
Write a reviewThe potency and power of this protein met my expectations.
There are no adverse reactions and few side effects.
The quality of this one is very good, and they also have a long lifespan, and I am very satisfied with this product.
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