Recombinant Full Length Human GRIK2 Protein, C-Flag-tagged

• Cat.No.: GRIK2-1566HFL
• Product Overview: Recombinant Full Length Human GRIK2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 98.9 kDa
• AA Sequence: MKIIFPILSNPVFRRTVKLLLCLLW IGYSQGTTHVLRFGGIFEYVESGPM GAEELAFRFAVNTINRNRTL LPNTTLTYDTQKINLYDSFEASKKA CDQLSLGVAAIFGPSHSSSANAVQS ICNALGVPHIQTRWKHQVSD NKDSFYVSLYPDFSSLSRAILDLVQ FFKWKTVTVVYDDSTGLIRLQELIK APSRYNLRLKIRQLPADTKD AKPLLKEMKRGKEFHVIFDCSHEMA AGILKQALAMGMMTEYYHYIFTTLD LFALDVEPYRYSGVNMTGFR ILNTENTQVSSIIEKWSMERLQAPP KPDSGLLDGFMTTDAALMYDAVHVV SVAVQQFPQMTVSSLQCNRH KPWRFGTRFMSLIKEAHWEGLTGRI TFNKTNGLRTDFDLDVISLKEEGLE KIGTWDPASGLNMTESQKGK PANITDSLSNRSLIVTTILEEPYVL FKKSDKPLYGNDRFEGYCIDLLREL STILGFTYEIRLVEDGKYGA QDDANGQWNGMVRELIDHKADLAVA PLAITYVREKVIDFSKPFMTLGISI LYRKPNGTNPGVFSFLNPLS PDIWMYVLLAYLGVSCVLFVIARFS PYEWYNPHPCNPDSDVVENNFTLLN SFWFGVGALMRQGSELMPKA LSTRIVGGIWWFFTLIIISSYTANL AAFLTVERMESPIDSADDLAKQTKI EYGAVEDGATMTFFKKSKIS TYDKMWAFMSSRRQSVLVKSNEEGI QRVLTSDYAFLMESTTIEFVTQRNC NLTQIGGLIDSKGYGVGTPM GSPYRDKITIAILQLQEEGKLHMMK EKWWRGNGCPEEESKEASALGVQNI GGIFIVLAAGLVLSVFVAVG EFLYKSKKNAQLEKRSFCSAMVEEL RMSLKCQRRLKHKPQAPVIVKTEEV INMHTFNDRRLPGKETMATRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: GRIK2 glutamate ionotropic receptor kainate type subunit 2 [ Homo sapiens (human) ]
• Official Symbol: GRIK2
• Synonyms: EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2; NEDLAS
• Gene ID: 2898
• mRNA Refseq: NM_021956.5
• Protein Refseq: NP_068775.1
• MIM: 138244
• UniProt ID: Q13002