Recombinant Full Length Human GRIN1 Protein
Cat.No. : | GRIN1-5664HF |
Product Overview : | Human GRIN1 full-length ORF (AAI56098.1) recombinant protein without tag. |
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Description : | The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Form : | Liquid |
Molecular Mass : | 103.2 kDa |
Protein Length : | 419 amino acids |
AA Sequence : | MSTMRLLTLALLFSCSVARAACDPK IVNIGAVLSTRKHEQMFREAVNQAN KRHGSWKIQLNATSVTHKPNAIQMA LSVCEDLISSQVYAILVSHPPTPND HFTPTPVSYTAGFYRIPVLGLTTRM SIYSDKSIHLSFLRTVPPYSHQSSV WFEMMRVYSWNHIILLVSDDHEGRA AQKRLETLLEERESKAEKVLQFDPG TKNVTALLMEAKELEARVIILSASE DDAATVYRAAAMLNMTGSGYVWLVG EREISGNALRYAPDGILGLQLINGK NESAHISDAVGVVAQAVHELLEKEN ITDPPRGCVGNTNIWKTGPLFKRVL MSSKYADGVTGRVEFNEDGDRKFAN YSIMNLQNRKLVQVGIYNGTHVIPN DRKIIWPGGETEKPRGYQMSTRLKI VTIHQEPFVYVKPTLSDGTCKEEFT VNGDPVKKVICTGPNDTSPGSPRHT VPQCCYGFCIDLLIKLARTMNFTYE VHLVADGKFGTQERVNNSNKKEWNG MMGELLSGQADMIVAPLTINNERAQ YIEFSKPFKYQGLTILVKKEIPRST LDSFMQPFQSTLWLLVGLSVHVVAV MLYLLDRFSPFGRFKVNSEEEEEDA LTLSSAMWFSWGVLLNSGIGEGAPR SFSARILGMVWAGFAMIIVASYTAN LAAFLVLDRPEERITGINDPRLRNP SDKFIYATVKQSSVDIYFRRQVELS TMYRHMEKHNYESAAEAIQAVRDNK LHAFIWDSAVLEFEASQKCDLVTTG ELFFRSGFGIGMRKDSPWKQNVSLS ILKSHENGFMEDLDKTWVRYQECDS RSNAPATLTFENMAGVFMLVAGGIV AGIFLIFIEIAYKRHKDARRKQMQL AFAAVNVWRKNLQDRKSGRAEPDPK KKATFRAITSTLASSFKRRRSSKDT STGGGRGALQNQKDTVLPRRAIERE EGQLQLCSRHRES |
Applications : | Antibody Production Functional Study Compound Screening |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Gene Name : | GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 [ Homo sapiens ] |
Official Symbol : | GRIN1 |
Synonyms : | GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1; NMDAR1; glutamate [NMDA] receptor subunit zeta-1; GluN1; NMD-R1; glutamate [NMDA] receptor subunit zeta 1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1; NR1; MRD8; NMDA1; |
Gene ID : | 2902 |
mRNA Refseq : | NM_000832 |
Protein Refseq : | NP_000823 |
MIM : | 138249 |
UniProt ID : | Q05586 |
Products Types
◆ Recombinant Protein | ||
GRIN1-5344H | Recombinant Human GRIN1 Protein, GST-tagged | +Inquiry |
GRIN1-2361H | Recombinant Human GRIN1 Protein, MYC/DDK-tagged | +Inquiry |
GRIN1-2992H | Recombinant Human GRIN1 protein(19-559aa), 6xHis-tagged | +Inquiry |
GRIN1-5343H | Recombinant Human GRIN1 Protein | +Inquiry |
GRIN1-2354R | Recombinant Rat GRIN1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
GRIN1-5745HCL | Recombinant Human GRIN1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDysregulation of the NMDA receptor, due to GRIN1 mutations, has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's.
Disorders such as epilepsy, autism spectrum disorders, and schizophrenia have been linked to GRIN1 mutations.
Yes, genetic testing can identify mutations in the GRIN1 gene, which may be helpful in diagnosing certain neurological conditions.
The NMDA receptor, with GRIN1 as a subunit, is crucial for long-term potentiation, a process underlying memory formation and learning.
Some studies suggest that genetic variations in GRIN1 may influence an individual's response to antidepressant medications.
Customer Reviews (3)
Write a reviewThis strong track record of excellence further attests to the GRIN1 protein's capability to meet the rigorous demands of research projects.
Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.
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