Recombinant Full Length Human GRIN1 Protein, C-Flag-tagged

• Cat.No.: GRIN1-418HFL
• Product Overview: Recombinant Full Length Human GRIN1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 103.4 kDa
• AA Sequence: MSTMRLLTLALLFSCSVARAACDPK IVNIGAVLSTRKHEQMFREAVNQAN KRHGSWKIQLNATSVTHKPN AIQMALSVCEDLISSQVYAILVSHP PTPNDHFTPTPVSYTAGFYRIPVLG LTTRMSIYSDKSIHLSFLRT VPPYSHQSSVWFEMMRVYSWNHIIL LVSDDHEGRAAQKRLETLLEERESK AEKVLQFDPGTKNVTALLME AKELEARVIILSASEDDAATVYRAA AMLNMTGSGYVWLVGEREISGNALR YAPDGILGLQLINGKNESAH ISDAVGVVAQAVHELLEKENITDPP RGCVGNTNIWKTGPLFKRVLMSSKY ADGVTGRVEFNEDGDRKFAN YSIMNLQNRKLVQVGIYNGTHVIPN DRKIIWPGGETEKPRGYQMSTRLKI VTIHQEPFVYVKPTLSDGTC KEEFTVNGDPVKKVICTGPNDTSPG SPRHTVPQCCYGFCIDLLIKLARTM NFTYEVHLVADGKFGTQERV NNSNKKEWNGMMGELLSGQADMIVA PLTINNERAQYIEFSKPFKYQGLTI LVKKEIPRSTLDSFMQPFQS TLWLLVGLSVHVVAVMLYLLDRFSP FGRFKVNSEEEEEDALTLSSAMWFS WGVLLNSGIGEGAPRSFSAR ILGMVWAGFAMIIVASYTANLAAFL VLDRPEERITGINDPRLRNPSDKFI YATVKQSSVDIYFRRQVELS TMYRHMEKHNYESAAEAIQAVRDNK LHAFIWDSAVLEFEASQKCDLVTTG ELFFRSGFGIGMRKDSPWKQ NVSLSILKSHENGFMEDLDKTWVRY QECDSRSNAPATLTFENMAGVFMLV AGGIVAGIFLIFIEIAYKRH KDARRKQMQLAFAAVNVWRKNLQDR KSGRAEPDPKKKATFRAITSTLASS FKRRRSSKDTSTGGGRGALQ
  NQKDTVLPRRAIEREEGQLQLCSRH RESTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Calcium signaling pathway, Huntington's disease, Long-term potentiation, Neuroactive ligand-receptor interaction

Gene Information

• Gene Name: GRIN1 glutamate ionotropic receptor NMDA type subunit 1 [ Homo sapiens (human) ]
• Official Symbol: GRIN1
• Synonyms: NR1; MRD8; GluN1; NMDA1; DEE101; NDHMSD; NDHMSR; NMD-R1; NMDAR1
• Gene ID: 2902
• mRNA Refseq: NM_007327.4
• Protein Refseq: NP_015566.1
• MIM: 138249
• UniProt ID: Q05586

Reviews

02/25/2022

This strong track record of excellence further attests to the GRIN1 protein's capability to meet the rigorous demands of research projects.

12/02/2019

Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.

07/01/2016

Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

Q&As

How is the GRIN1 protein involved in neurodegenerative diseases?

Dysregulation of the NMDA receptor, due to GRIN1 mutations, has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's.

What neurological disorders are associated with GRIN1 mutations?

Disorders such as epilepsy, autism spectrum disorders, and schizophrenia have been linked to GRIN1 mutations.

Is there a genetic test for GRIN1 mutations?

Yes, genetic testing can identify mutations in the GRIN1 gene, which may be helpful in diagnosing certain neurological conditions.

How does the GRIN1 protein contribute to synaptic plasticity?

The NMDA receptor, with GRIN1 as a subunit, is crucial for long-term potentiation, a process underlying memory formation and learning.

Can variations in the GRIN1 gene affect response to antidepressants?

Some studies suggest that genetic variations in GRIN1 may influence an individual's response to antidepressant medications.