Recombinant Full Length Human GSDMB Protein, C-Flag-tagged

• Cat.No.: GSDMB-1028HFL
• Product Overview: Recombinant Full Length Human GSDMB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.2 kDa
• AA Sequence: MFSVFEEITRIVVKEMDAGGDMIAV RSLVDADRFRCFHLVGEKRTFFGCR HYTTGLTLMDILDTDGDKWL DELDSGLQGQKAEFQILDNVDSTGE LIVRLPKEITISGSFQGFHHQKIKI SENRISQQYLATLENRKLKR ELPFSFRSINTRENLYLVTETLETV KEETLKSDRQYKFWSQISQGHLSYK HKGQREVTIPPNRVLSYRVK QLVFPNKETMNIHFRGKTKSFPEEK DGASSCLGKSLGSEDSRNMKEKLED MESVLKDLTEEKRKDVLNSL AKCLGKEDIRQDLEQRVSEVLISGE LHMEDPDKPLLSSLFNAAGVLVEAR AKAILDFLDALLELSEEQQF VAEALEKGTLPLLKDQVKSVMEQNW DELASSPPDMDYDPEARILCALYVV VSILLELAEGPTSVSSTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: GSDMB gasdermin B [ Homo sapiens (human) ]
• Official Symbol: GSDMB
• Synonyms: GSDML; PP4052; GSDMB-1; PRO2521
• Gene ID: 55876
• mRNA Refseq: NM_001165958.2
• Protein Refseq: NP_001159430.1
• MIM: 611221
• UniProt ID: Q8TAX9