Recombinant Full Length Human HAO1 Protein, GST-tagged
Cat.No. : | HAO1-3351HF |
Product Overview : | Human HAO1 full-length ORF ( NP_060015.1, 1 a.a. - 370 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 67.3 kDa |
Protein Length : | 370 amino acids |
AA Sequence : | MLPRLICINDYEQHAKSVLPKSIYD YYRSGANDEETLADNIAAFSRWKLY PRMLRNVAETDLSTSVLGQRVSMPI CVGATAMQRMAHVDGELATVRACQS LGTGMMLSSWATSSIEEVAEAGPEA LRWLQLYIYKDREVTKKLVRQAEKM GYKAIFVTVDTPYLGNRLDDVRNRF KLPPQLRMKNFETSTLSFSPEENFG DDSGLAAYVAKAIDPSISWEDIKWL RRLTSLPIVAKGILRGDDAREAVKH GLNGILVSNHGARQLDGVPATIDVL PEIVEAVEGKVEVFLDGGVRKGTDV LKALALGAKAVFVGRPIVWGLAFQG EKGVQDVLEILKEEFRLAMALSGCQ NVKVIDKTLVRKNPLAVSKI |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | HAO1 hydroxyacid oxidase (glycolate oxidase) 1 [ Homo sapiens ] |
Official Symbol : | HAO1 |
Synonyms : | HAO1; hydroxyacid oxidase (glycolate oxidase) 1; GOX1; hydroxyacid oxidase 1; GOX; glycolate oxidase; (S)-2-hydroxy-acid oxidase; HAOX1; MGC142225; MGC142227; |
Gene ID : | 54363 |
mRNA Refseq : | NM_017545 |
Protein Refseq : | NP_060015 |
MIM : | 605023 |
UniProt ID : | Q9UJM8 |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.
Therapeutic approaches may include modulation of HAO1 activity or expression.
It oxidizes specific fatty acids, contributing to their breakdown.
HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.
HAO1 overexpression may lead to oxidative stress and liver dysfunction.
HAO1 supports liver function by participating in lipid catabolism.
Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.
Customer Reviews (3)
Write a reviewWorked well in experiments.
Great for academic research.
Very satisfied, will buy again.
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