Recombinant Full Length Human HEXIM2 Protein, C-Flag-tagged

• Cat.No.: HEXIM2-2162HFL
• Product Overview: Recombinant Full Length Human HEXIM2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the HEXIM family of proteins. This protein is a component of the 7SK small nuclear ribonucleoprotein. This protein has been found to negatively regulate the kinase activity of the cyclin-dependent kinase P-TEFb, which phosphorylates multiple target proteins to promote transcriptional elongation. This gene is located approximately 7 kb downstream from related family member HEXIM1 on chromosome 17. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 32.2 kDa
• AA Sequence: MMATPNQTACNAESPVALEEAKTSG APGSPQTPPERHDSGGSLPLTPRME SHSEDEDLAGAVGGLGWNSR SPRTQSPGGCSAEAVLARKKHRRRP SKRKRHWRPYLELSWAEKQQRDERQ SQRASRVREEMFAKGQPVAP YNTTQFLMNDRDPEEPNLDVPHGIS HPGSSGESEAGDSDGRGRAHGEFQR KDFSETYERFHTESLQGRSK QELVRDYLELEKRLSQAEEETRRLQ QLQACTGQQSCRQVEELAAEVQRLR TENQRLRQENQMWNREGCRC DEEPGT TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transcription Factors

Gene Information

• Gene Name: HEXIM2 HEXIM P-TEFb complex subunit 2 [ Homo sapiens (human) ]
• Official Symbol: HEXIM2
• Synonyms: L3
• Gene ID: 124790
• mRNA Refseq: NM_144608.2
• Protein Refseq: NP_653209.1
• MIM: 615695
• UniProt ID: Q96MH2