Recombinant Full Length Human HSPA8 Protein, GST-tagged
Cat.No. : | HSPA8-3962HF |
Product Overview : | Human HSPA8 full-length ORF ( AAH16179, 1 a.a. - 646 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. [provided by RefSeq |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 96.80 kDa |
Protein Length : | 646 amino acids |
AA Sequence : | MSKGPAVGIDLGTTYSCVGVFQHGK VEIIANDQGNRTTPSYVAFTDTERL IGDAAKNQVAMNPTNTVFDAKRLIG RRFDDAVVQSDMKHWPFMVVNDAGR PKVQVEYKGETKSFYPEEVSSMVLT KMKEIAEAYLGKTVTNAVVTVPAYF NDSQRQATKDAGTIAGLNVLRIINE PTAAAIAYGLDKKVGAERNVLIFDL GGGTFDVSILTIEDGIFEVKSTAGD THLGGEDFDNRMVNHFIAEFKRKHK KDISENKRAVRRLRTACERAKRTLS SSTQASIEIDSLYEGIDFYTSITRA RFEELNADLFRGTLDPVEKALRDAK LDKSQIHDIVLVGGSTRIPKIQKLL QDFFNGKELNKSINPDEAVAYGAAV QAAILSGDKSENVQDLLLLDVTPLS LGIETAGGVMTVLIKRNTTIPTKQT QTFTTYSDNQPGVLIQVYEGERAMT KDNNLLGKFELTGIPPAPRGVPQIE VTFDIDANGILNVSAVDKSTGKENK ITITNDKGRLSKEDIERMVQEAEKY KAEDEKQRDKVSSKNSLESYAFNMK ATVEDEKLQGKINDEDKQKILDKCN EIINWLDKNQTAEKEEFEHQQKELE KVCNPIITKLYQSAGGMPGGMPGGF PGGGAPPSGGASSGPTIEEVD |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -8 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ] |
Official Symbol : | HSPA8 |
Synonyms : | HSPA8; heat shock 70kDa protein 8; heat shock 70kD protein 8 , HSPA10; heat shock cognate 71 kDa protein; HSC70; HSC71; HSP73; LPS-associated protein 1; heat shock 70kd protein 10; heat shock cognate protein 54; constitutive heat shock protein 70; lipopolysaccharide-associated protein 1; N-myristoyltransferase inhibitor protein 71; LAP1; HSC54; HSP71; NIP71; HSPA10; MGC29929; MGC131511; |
Gene ID : | 3312 |
mRNA Refseq : | NM_006597 |
Protein Refseq : | NP_006588 |
MIM : | 600816 |
UniProt ID : | P11142 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionHSPA8 is a central player in the heat shock response, assisting in the refolding of denatured proteins. It modulates downstream pathways such as HSF1 activation, orchestrating a cellular survival response.
HSPA8 plays a role in neurodegenerative diseases, mitigating protein aggregation and neuronal dysfunction. Its chaperone activity is crucial for maintaining protein homeostasis in the nervous system.
HSPA8 exhibits anti-apoptotic functions by interacting with pro-apoptotic proteins and preventing their activation. Its role in apoptosis regulation contributes to cell survival during stress.
HSPA8 is involved in autophagy, facilitating the clearance of misfolded proteins and damaged organelles. It interacts with autophagy receptors, promoting their recognition by autophagosomes.
HSPA8 participates in antigen presentation and modulates immune cell functions. It chaperones antigens for presentation on major histocompatibility complexes, influencing immune recognition and response.
Customer Reviews (3)
Write a reviewThe lab product's precision and quality are noteworthy.
The customer service team was accommodating, and the delivery exceeded my expectations.
This lab product is synonymous with excellence.
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