Recombinant Full Length Human IFI16 Protein, C-Flag-tagged

• Cat.No.: IFI16-190HFL
• Product Overview: Recombinant Full Length Human IFI16 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 81.9 kDa
• AA Sequence: MGKKYKNIVLLKGLEVINDYHFRMV KSLLSNDLKLNLKMREEYDKIQIAD LMEEKFRGDAGLGKLIKIFE DIPTLEDLAETLKKEKLKVKGPALS RKRKKEVHATSPAPSTSSTVKTEGA EATPGAQKRKKSTKEKAGPK GSKVSEEQTQPPSPAGAGMSTAMGR SPSPKTSLSAPPNSSSTENPKTVAK CQVTPRRNVLQKRPVIVKVL STTKPFEYETPEMEKKIMFHATVAT QTQFFHVKVLNTSLKEKFNGKKIII ISDYLEYDSLLEVNEESTVS EAGPNQTFEVPNKIINRAKETLKID ILHKQASGNIVYGVFMLHKKTVNQK TTIYEIQDDRGKMDVVGTGQ CHNIPCEEGDKLQLFCFRLRKKNQM SKLISEMHSFIQIKKKTNPRNNDPK SMKLPQEQRQLPYPSEASTT FPESHLRTPQMPPTTPSSSFFTKKS EDTISKMNDFMRMQILKEGSHFPGP FMTSIGPAESHPHTPQMPPS TPSSSFLTTLKPRLKTEPEEVSIED SAQSDLKEVMVLNATESFVYEPKEQ KKMFHATVATENEVFRVKVF NIDLKEKFTPKKIIAIANYVCRNGF LEVYPFTLVADVNADRNMEIPKGLI RSASVTPKINQLCSQTKGSF VNGVFEVHKKNVRGEFTYYEIQDNT GKMEVVVHGRLNTINCEEGDKLKLT SFELAPKSGNTGELRSVIHS
  HIKVIKTRKNKKDILNPDSSMETSP DFFFTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transcription Factors

Gene Information

• Gene Name: IFI16 interferon gamma inducible protein 16 [ Homo sapiens (human) ]
• Official Symbol: IFI16
• Synonyms: PYHIN2; IFNGIP1
• Gene ID: 3428
• mRNA Refseq: NM_005531.3
• Protein Refseq: NP_005522.2
• MIM: 147586
• UniProt ID: Q16666