Recombinant Full Length Human ITGA2B Protein, C-Flag-tagged

• Cat.No.: ITGA2B-1152HFL
• Product Overview: Recombinant Full Length Human ITGA2B Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 110 kDa
• AA Sequence: MARALCPLQALWLLEWVLLLLGPCA APPAWALNLDPVQLTFYAGPNGSQF GFSLDFHKDSHGRVAIVVGA PRTLGPSQEETGGVFLCPWRAEGGQ CPSLLFDLRDETRNVGSQTLQTFKA RQGLGASVVSWSDVIVACAP WQHWNVLEKTEEAEKTPVGSCFLAQ PESGRRAEYSPCRGNTLSRIYVEND FSWDKRYCEAGFSSVVTQAG ELVLGAPGGYYFLGLLAQAPVADIF SSYRPGILLWHVSSQSLSFDSSNPE YFDGYWGYSVAVGEFDGDLN TTEYVVGAPTWSWTLGAVEILDSYY QRLHRLRGEQMASYFGHSVAVTDVN GDGRHDLLVGAPLYMESRAD RKLAEVGRVYLFLQPRGPHALGAPS LLLTGTQLYGRFGSAIAPLGDLDRD GYNDIAVAAPYGGPSGRGQV LVFLGQSEGLRSRPSQVLDSPFPTG SAFGFSLRGAVDIDDNGYPDLIVGA YGANQVAVYRAQPVVKASVQ LLVQDSLNPAVKSCVLPQTKTPVSC FNIQMCVGATGHNIPQKLSLNAELQ LDRQKPRQGRRVLLLGSQQA GTTLNLDLGGKHSPICHTTMAFLRD EADFRDKLSPIVLSLNVSLPPTEAG MAPAVVLHGDTHVQEQTRIV LDCGEDDVCVPQLQLTASVTGSPLL VGADNVLELQMDAANEGEGAYEAEL AVHLPQGAHYMRALSNVEGF ERLICNQKKENETRVVLCELGNPMK KNAQIGIAMLVSVGNLEEAGESVSF QLQIRSKNSQNPNSKIVLLD VPVRAEAQVELRGNSFPASLVVAAE EGEREQNSLDSWGPKVEHTYELHNN GPGTVNGLHLSIHLPGQSQP SDLLYILDIQPQGGLQCFPQPPVNP LKVDWGLPIPSPSPIHPAHHKRDRR QIFLPEPEQPSRLQDPVLVS CDSAPCTVVQCDLQEMARGQRAMVT VLAFLWLPSLYQRPLDQFVLQSHAW FNVSSLPYAVPPLSLPRGEA
  QVWTQLLRALEERAIPIWWVLVGVL GGLLLLTILVLAMWKVGFFKRNRPP LEEDDEEGETRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer

Gene Information

• Gene Name: ITGA2B integrin subunit alpha 2b [ Homo sapiens (human) ]
• Official Symbol: ITGA2B
• Synonyms: GT; GT1; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93
• Gene ID: 3674
• mRNA Refseq: NM_000419.5
• Protein Refseq: NP_000410.2
• MIM: 607759
• UniProt ID: P08514