Recombinant Full Length Human JPH2 Protein, C-Flag-tagged

• Cat.No.: JPH2-1548HFL
• Product Overview: Recombinant Full Length Human JPH2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 74 kDa
• AA Sequence: MSGGRFDFDDGGAYCGGWEGGKAHG HGLCTGPKGQGEYSGSWNFGFEVAG VYTWPSGNTFEGYWSQGKRH GLGIETKGRWLYKGEWTHGFKGRYG IRQSSSSGAKYEGTWNNGLQDGYGT ETYADGGTYQGQFTNGMRHG YGVRQSVPYGMAVVVRSPLRTSLSS LRSEHSNGTVAPDSPASPASDGPAL PSPAIPRGGFALSLLANAEA AARAPKGGGLFQRGALLGKLRRAES RTSVGSQRSRVSFLKSDLSSGASDA ASTASLGEAAEGADEAAPFE ADIDATTTETYMGEWKNDKRSGFGV SERSSGLRYEGEWLDNLRHGYGCTT LPDGHREEGKYRHNVLVKDT KRRMLQLKSNKVRQKVEHSVEGAQR AAAIARQKAEIAASRTSHAKAKAEA AEQAALAANQESNIARTLAR ELAPDFYQPGPEYQKRRLLQEILEN SESLLEPPDRGAGAAGLPQPPRESP QLHERETPRPEGGSPSPAGT PPQPKRPRPGVSKDGLLSPGAWNGE PSGEGSRSVTPSEGAGRRSPARPAT ERMAIEALQAPPAPSREPEV ALYQGYHSYAVRTTPPEPPPFEDQP EPEVSGSESAPSSPATAPLQAPTLR GPEPARETPAKLEPKPIIPK AEPRAKARKTEARGLTKAGAKKKAR KEAALAAEAEVEVEEVPNTILICMV ILLNIGLAILFVHLLTTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transmembrane

Gene Information

• Gene Name: JPH2 junctophilin 2 [ Homo sapiens (human) ]
• Official Symbol: JPH2
• Synonyms: JP2; JP-2; CMD2E; CMH17
• Gene ID: 57158
• mRNA Refseq: NM_020433.5
• Protein Refseq: NP_065166.2
• MIM: 605267
• UniProt ID: Q9BR39