Recombinant Full Length Human KDSR Protein, C-Flag-tagged

• Cat.No.: KDSR-1045HFL
• Product Overview: Recombinant Full Length Human KDSR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 33.4 kDa
• AA Sequence: MLLLAAAFLVAFVLLLYMVSPLISP KPLALPGAHVVVTGGSSGIGKCIAI ECYKQGAFITLVARNEDKLL QAKKEIEMHSINDKQVVLCISVDVS QDYNQVENVIKQAQEKLGPVDMLVN CAGMAVSGKFEDLEVSTFER LMSINYLGSVYPSRAVITTMKERRV GRIVFVSSQAGQLGLFGFTAYSASK FAIRGLAEALQMEVKPYNVY ITVAYPPDTDTPGFAEENRTKPLET RLISETTSVCKPEQVAKQIVKDAIQ GNFNSSLGSDGYMLSALTCG
  MAPVTSITEGLQQVVTMGLFRTIAL FYLGSFDSIVRRCMMQREKSENADK TATRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism

Gene Information

• Gene Name: KDSR 3-ketodihydrosphingosine reductase [ Homo sapiens (human) ]
• Official Symbol: KDSR
• Synonyms: DHSR; FVT1; EKVP4; SDR35C1
• Gene ID: 2531
• mRNA Refseq: NM_002035.4
• Protein Refseq: NP_002026.1
• MIM: 136440
• UniProt ID: Q06136