Recombinant Full Length Human KRT18 Protein, GST-tagged

• Cat.No.: KRT18-5928HF
• Product Overview: Human KRT18 full-length ORF ( AAH20982, 1 a.a. - 430 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 72.82 kDa
• Protein Length: 430 amino acids
• AA Sequence: MSFTTRSTFSTNYRSLGSVQAPSYG ARPVSSAASVYAGAGGSGSRISVSR STSFRGGMGSGGLATGIAGGLAGMG GIQNEKETMQSLNDRLASYLDRVRS LETENRRLESKIREHLEKKGPQVRD WSHYFKIIEDLRAQIFANTVDNARI VLQIDNARLAADDFRVKYETELAMR QSVENDIHGLRKVIDDTNITRLQLE TEIEALKEELLFMKKNHEEEVKGLQ AQIASSGLTVEVDAPKSQDLAKIMA DIRAQYDELARKNREELDKYWSQQI EESTTVVTTQSAEVGAAETTLTELR RTVQSLEIDLDSMRNLKASLENSLR EVEARYALQMEQLNGILLHLESELA QTRAEGQRQAQEYEALLNIKVKLEA EIATYRRLLEDGEDFNLGDALDSSN SMQTIQKTTTRRIVDGKVVSETNDT KVLRH
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: KRT18 keratin 18 [ Homo sapiens ]
• Official Symbol: KRT18
• Synonyms: KRT18; keratin 18; keratin, type I cytoskeletal 18; CK-18; keratin-18; cytokeratin 18; cytokeratin-18; cell proliferation-inducing protein 46; cell proliferation-inducing gene 46 protein; K18; CYK18
• Gene ID: 3875
• mRNA Refseq: NM_000224
• Protein Refseq: NP_000215
• MIM: 148070
• UniProt ID: P05783

Reviews

01/17/2022

The sensitivity is very high, the experimental results are very good, and the unnecessary trouble is reduced.

10/31/2021

No doping impurities, the experimental effect is very good, will be recommended to other laboratory students.

01/03/2021

Easy to operate, cost-effective.

Q&As

What is the relationship between KRT18 protein and nail diseases?

KRT18 protein may be associated with nail diseases, such as brittle nails, white spots, and longitudinal cracks. These diseases can affect the hardness and structure of the nails, causing them to appear brittle, deformed, and painful.

What is the relationship between KRT18 protein and hair color?

KRT18 protein is not directly related to hair color. Hair color is mainly determined by melanocytes, while the KRT18 protein is mainly involved in the process of keratinization.

How can genetic testing be used to understand the genetic variation of KRT18 protein?

Genetic testing can be done by analyzing DNA sequences to understand genetic variation in the KRT18 protein. These variants may affect the expression level and function of the KRT18 protein, thereby increasing the risk of certain diseases.

How can lifestyle changes affect the function of KRT18 protein?

Lifestyle changes, such as eating a healthy diet, exercising moderately, and avoiding UV damage, can affect the function and expression levels of KRT18 protein. These alterations can promote the normal function of keratinocytes, which can help maintain healthy skin.

How can KRT18 protein-related diseases be prevented?

Prevention of KRT18 protein-related diseases is mainly through maintaining a healthy lifestyle, such as a balanced diet, moderate exercise, maintaining water intake, and avoiding UV damage. In addition, regular skin and oral exams can also help detect potential problems early.

What is the role of KRT18 protein in melanoma?

In melanoma, the KRT18 protein may play a role in promoting tumor growth and metastasis. This may be related to the proliferation and migration of melanoma cells.