Recombinant Full Length Human LCP2 Protein, C-Flag-tagged

• Cat.No.: LCP2-587HFL
• Product Overview: Recombinant Full Length Human LCP2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 60 kDa
• AA Sequence: MALRNVPFRSEVLGWDPDSLADYFK KLNYKDCEKAVKKYHIDGARFLNLT ENDIQKFPKLRVPILSKLSQ EINKNEERRSIFTRKPQVPRFPEET ESHEEDNGGWSSFEEDDYESPNDDQ DGEDDGDYESPNEEEEAPVE DDADYEPPPSNDEEALQNSILPAKP FPNSNSMYIDRPPSGKTPQQPPVPP QRPMAALPPPPAGRNHSPLP PPQTNHEEPSRSRNHKTAKLPAPSI DRSTKPPLDRSLAPFDREPFTLGKK PPFSDKPSIPAGRSLGEHLP KIQKPPLPPTTERHERSSPLPGKKP PVPKHGWGPDRRENDEDDVHQRPLP QPALLPMSSNTFPSRSTKPS PMNPLPSSHMPGAFSESNSSFPQSA SLPPYFSQGPSNRPPIRAEGRNFPL PLPNKPRPPSPAEEENSLNE EWYVSYITRPEAEAALRKINQDGTF LVRDSSKKTTTNPYVLMVLYKDKVY NIQIRYQKESQVYLLGTGLR
  GKEDFLSVSDIIDYFRKMPLLLIDG KNRGSRYQCTLTHAAGYPTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Pathways: Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

Gene Information

• Gene Name: LCP2 lymphocyte cytosolic protein 2 [ Homo sapiens (human) ]
• Official Symbol: LCP2
• Synonyms: IMD81; SLP76; SLP-76
• Gene ID: 3937
• mRNA Refseq: NM_005565.5
• Protein Refseq: NP_005556.1
• MIM: 601603
• UniProt ID: Q13094