Recombinant Full Length Human LDLR Protein, C-Flag-tagged
Cat.No. : | LDLR-1033HFL |
Product Overview : | Recombinant Full Length Human LDLR Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 93 kDa |
AA Sequence : | MGPWGWKLRWTVALLLAAAGTAVGD RCERNEFQCQDGKCISYKWVCDGSA ECQDGSDESQETCLSVTCKS GDFSCGGRVNRCIPQFWRCDGQVDC DNGSDEQGCPPKTCSQDEFRCHDGK CISRQFVCDSDRDCLDGSDE ASCPVLTCGPASFQCNSSTCIPQLW ACDNDPDCEDGSDEWPQRCRGLYVF QGDSSPCSAFEFHCLSGECI HSSWRCDGGPDCKDKSDEENCAVAT CRPDEFQCSDGNCIHGSRQCDREYD CKDMSDEVGCVNVTLCEGPN KFKCHSGECITLDKVCNMARDCRDW SDEPIKECGTNECLDNNGGCSHVCN DLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGGY KCQCEEGFQLDPHTKACKAVGSIAY LFFTNRHEVRKMTLDRSEYT SLIPNLRNVVALDTEVASNRIYWSD LSQRMICSTQLDRAHGVSSYDTVIS RDIQAPDGLAVDWIHSNIYW TDSVLGTVSVADTKGVKRKTLFREN GSKPRAIVVDPVHGFMYWTDWGTPA KIKKGGLNGVDIYSLVTENI QWPNGITLDLLSGRLYWVDSKLHSI SSIDVNGGNRKTILEDEKRLAHPFS LAVFEDKVFWTDIINEAIFS ANRLTGSDVNLLAENLLSPEDMVLF HNLTQPRGVNWCERTTLSNGGCQYL CLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETS TVRLKVSSTAVRTQHTTTRPVPDTS RLPGATPGLTTVEIVTMSHQ ALGDVAGRGNEKKPSSVRALSIVLP IVLLVFLCLGVFLLWKNWRLKNINS INFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVATRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways : | Endocytosis |
Gene Name : | LDLR low density lipoprotein receptor [ Homo sapiens (human) ] |
Official Symbol : | LDLR |
Synonyms : | FH; FHC; FHCL1; LDLCQ2 |
Gene ID : | 3949 |
mRNA Refseq : | NM_000527.5 |
Protein Refseq : | NP_000518.1 |
MIM : | 606945 |
UniProt ID : | P01130 |
Products Types
◆ Recombinant Protein | ||
LDLR-348H | Recombinant Human LDLR Protein, Fc-tagged | +Inquiry |
LDLR-347H | Recombinant Human LDLR Protein, His-tagged | +Inquiry |
LDLR-275H | Recombinant Human LDLR Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
LDLR-344H | Recombinant Human LDLR Protein, His-tagged | +Inquiry |
LDLR-345C | Recombinant Cynomolgus monkey LDLR Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
LDLR-85H | Native Human Lipoprotein | +Inquiry |
◆ Lysates | ||
LDLR-2762MCL | Recombinant Mouse LDLR cell lysate | +Inquiry |
LDLR-2780HCL | Recombinant Human LDLR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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