Recombinant Full Length Human LNPEP Protein, C-Flag-tagged

• Cat.No.: LNPEP-306HFL
• Product Overview: Recombinant Full Length Human LNPEP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 117.2 kDa
• AA Sequence: MEPFTNDRLQLPRNMIENSMFEEEP DVVDLAKEPCLHPLEPDEVEYEPRG SRLLVRGLGEHEMEEDEEDY ESSAKLLGMSFMNRSSGLRNSATGY RQSPDGACSVPSARTMVVCAFVIVV AVSVIMVIYLLPRCTFTKEG CHKKNQSIGLIQPFATNGKLFPWAQ IRLPTAVVPLRYELSLHPNLTSMTF RGSVTISVQALQVTWNIILH STGHNISRVTFMSAVSSQEKQAEIL EYAYHGQIAIVAPEALLAGHNYTLK IEYSANISSSYYGFYGFSYT DESNEKKYFAATQFEPLAARSAFPC FDEPAFKATFIIKIIRDEQYTALSN MPKKSSVVLDDGLVQDEFSE SVKMSTYLVAFIVGEMKNLSQDVNG TLVSIYAVPEKIGQVHYALETTVKL LEFFQNYFEIQYPLKKLDLV AIPDFEAGAMENWGLLTFREETLLY DSNTSSMADRKLVTKIIAHELAHQW FGNLVTMKWWNDLWLNEGFA TFMEYFSLEKIFKELSSYEDFLDAR FKTMKKDSLNSSHPISSSVQSSEQI EEMFDSLSYFKGSSLLLMLK TYLSEDVFQHAVVLYLHNHSYASIQ SDDLWDSFNEVTNQTLDVKRMMKTW TLQKGFPLVTVQKKGKELFI QQERFFLNMKPEIQPSDTSYLWHIP LSYVTEGRNYSKYQSVSLLDKKSGV INLTEEVLWVKVNINMNGYY IVHYADDDWEALIHQLKINPYVLSD KDRANLINNIFELAGLGKVPLKRAF DLINYLGNENHTAPITEALF QTDLIYNLLEKLGYMDLASRLVTRV FKLLQNQIQQQTWTDEGTPSMRELR SALLEFACTHNLGNCSTTAM KLFDDWMASNGTQSLPTDVMTTVFK VGAKTDKGWSFLLGKYISIGSEAEK NKILEALASSEDVRKLYWLM KSSLNGDNFRTQKLSFIIRTVGRHF PGHLLAWDFVKENWNKLVQKFPLGS YTIQNIVAGSTYLFSTKTHL
  SEVQAFFENQSEATFRLRCVQEALE VIQLNIQWMEKNLKSLTWWLTRTRP LEQKLISEEDLAANDILDYKDDDDK V
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system

Gene Information

• Gene Name: LNPEP leucyl and cystinyl aminopeptidase [ Homo sapiens (human) ]
• Official Symbol: LNPEP
• Synonyms: CAP; IRAP; PLAP; P-LAP
• Gene ID: 4012
• mRNA Refseq: NM_005575.3
• Protein Refseq: NP_005566.2
• MIM: 151300
• UniProt ID: Q9UIQ6