| Description : |
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
153 kDa |
| AA Sequence : |
MKAPAVLAPGILVLLFTLVQRSNGE CKEALAKSEMNVNMKYQLPNFTAET PIQNVILHEHHIFLGATNYI YVLNEEDLQKVAEYKTGPVLEHPDC FPCQDCSSKANLSGGVWKDNINMAL VVDTYYDDQLISCGSVNRGT CQRHVFPHNHTADIQSEVHCIFSPQ IEEPSQCPDCVVSALGAKVLSSVKD RFINFFVGNTINSSYFPDHP LHSISVRRLKETKDGFMFLTDQSYI DVLPEFRDSYPIKYVHAFESNNFIY FLTVQRETLDAQTFHTRIIR FCSINSGLHSYMEMPLECILTEKRK KRSTKKEVFNILQAAYVSKPGAQLA RQIGASLNDDILFGVFAQSK PDSAEPMDRSAMCAFPIKYVNDFFN KIVNKNNVRCLQHFYGPNHEHCFNR TLLRNSSGCEARRDEYRTEF TTALQRVDLFMGQFSEVLLTSISTF IKGDLTIANLGTSEGRFMQVVVSRS GPSTPHVNFLLDSHPVSPEV IVEHTLNQNGYTLVITGKKITKIPL NGLGCRHFQSCSQCLSAPPFVQCGW CHDKCVRSEECLSGTWTQQI CLPAIYKVFPNSAPLEGGTRLTICG WDFGFRRNNKFDLKKTRVLLGNESC TLTLSESTMNTLKCTVGPAM NKHFNMSIIISNGHGTTQYSTFSYV DPVITSISPKYGPMAGGTLLTLTGN YLNSGNSRHISIGGKTCTLK SVSNSILECYTPAQTISTEFAVKLK IDLANRETSIFSYREDPIVYEIHPT KSFISGGSTITGVGKNLNSV SVPRMVINVHEAGRNFTVACQHRSN SEIICCTTPSLQQLNLQLPLKTKAF FMLDGILSKYFDLIYVHNPV FKPFEKPVMISMGNENVLEIKGNDI DPEAVKGEVLKVGNKSCENIHLHSE AVLCTVPNDLLKLNSELNIE WKQAISSTVLGKVIVQPDQNFTGLI AGVVSISTALLLLLGFFLWLKKRKQ IKDLGSELVRYDARVHTPHL DRLVSARSVSPTTEMVSNESVDYRA TFPEDQFPNSSQNGSCRQVQYPLTD MSPILTSGDSDISSPLLQNT VHIDLSALNPELVQAVQHVVIGPSS LIVHFNEVIGRGHFGCVYHGTLLDN DGKKIHCAVKSLNRITDIGE VSQFLTEGIIMKDFSHPNVLSLLGI CLRSEGSPLVVLPYMKHGDLRNFIR NETHNPTVKDLIGFGLQVAK GMKYLASKKFVHRDLAARNCMLDEK FTVKVADFGLARDMYDKEYYSVHNK TGAKLPVKWMALESLQTQKF TTKSDVWSFGVLLWELMTRGAPPYP DVNTFDITVYLLQGRRLLQPEYCPD PLYEVMLKCWHPKAEMRPSF
SELVSRISAIFSTFIGEHYVHVNAT YVNVKCVAPYPSLLSSEDNADDEVD TRPASFWETSTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways : |
Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma |
