Recombinant Full Length Human NAGPA Protein, C-Flag-tagged
Cat.No. : | NAGPA-215HFL |
Product Overview : | Recombinant Full Length Human NAGPA Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 53.3 kDa |
AA Sequence : | MATSTGRWLLLRLALFGFLWEASGG LDSGASRDDDLLLPYPRARARLPRD CTRVRAGNREHESWPPPPAT PGAGGLAVRTFVSHFRDRAVAGHLT RAVEPLRTFSVLEPGGPGGCAARRR ATVEETARAADCRVAQNGGF FRMNSGECLGNVVSDERRVSSSGGL QNAQFGIRRDGTLVTGYLSEEEVLD TENPFVQLLSGVVWLIRNGS IYINESQATECDETQETGSFSKFVN VISARTAIGHDRKGQLVLFHADGQT EQRGINLWEMAEFLLKQDVV NAINLDGGGSATFVLNGTLASYPSD HCQDNMWRCPRQVSTVVCVHEPRCQ PPDCHGHGTCVDGYCQCTGH FWRGPGCDELDCGPSNCSQHGLCTE TGCRCDAGWTGSNCSEECPLGWHGP GCQRPCKCEHHCPCDPKTGN CSVSRVKQCLQPPEATLRAGELSFF TRTAWLALTLALAFLLLISIAANLS LLLSRAERNRRLHGDYAYHP LQEMNGEPLAAEKEQPGGAHNPFKD TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Transmembrane |
Protein Pathways : | Lysosome |
Gene Name : | NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [ Homo sapiens (human) ] |
Official Symbol : | NAGPA |
Synonyms : | UCE; APAA |
Gene ID : | 51172 |
mRNA Refseq : | NM_016256.4 |
Protein Refseq : | NP_057340.2 |
MIM : | 607985 |
UniProt ID : | Q9UK23 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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