Recombinant Full Length Human OSM Protein, C-Flag-tagged

• Cat.No.: OSM-945HFL
• Product Overview: Recombinant Full Length Human OSM Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 25.7 kDa
• AA Sequence: MGVLLTQRTLLSLVLALLFPSMASM AAIGSCSKEYRVLLGQLQKQTDLMQ DTSRLLDPYIRIQGLDVPKL REHCRERPGAFPSEETLRGLGRRGF LQTLNATLGCVLHRLADLEQRLPKA QDLERSGLNIEDLEKLQMAR PNILGLRNNIYCMAQLLDNSDTAEP TKAGRGASQPPTPTPASDAFQRKLE GCRFLHGYHRFMHSVGRVFS
  KWGESPNRSRRHSPHQALRKGVRRT RPSRKGKRLMTRGQLPRTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Gene Information

• Gene Name: OSM oncostatin M [ Homo sapiens (human) ]
• Official Symbol: OSM
• Synonyms: MGC20461
• Gene ID: 5008
• mRNA Refseq: NM_020530.6
• Protein Refseq: NP_065391.1
• MIM: 165095
• UniProt ID: P13725