Recombinant Full Length Human PPARG Protein, C-Flag-tagged

• Cat.No.: PPARG-1838HFL
• Product Overview: Recombinant Full Length Human PPARG Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 57.4 kDa
• AA Sequence: MGETLGDSPIDPESDSFTDTLSANI SQEMTMVDTEMPFWPTNFGISSVDL SVMEDHSHSFDIKPFTTVDF SSISTPHYEDIPFTRTDPVVADYKY DLKLQEYQSAIKVEPASPPYYSEKT QLYNKPHEEPSNSLMAIECR VCGDKASGFHYGVHACEGCKGFFRR TIRLKLIYDRCDLNCRIHKKSRNKC QYCRFQKCLAVGMSHNAIRF GRMPQAEKEKLLAEISSDIDQLNPE SADLRALAKHLYDSYIKSFPLTKAK ARAILTGKTTDKSPFVIYDM NSLMMGEDKIKFKHITPLQEQSKEV AIRIFQGCQFRSVEAVQEITEYAKS IPGFVNLDLNDQVTLLKYGV HEIIYTMLASLMNKDGVLISEGQGF MTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQAL ELQLKLNHPESSQLFAKLLQKMTDL RQIVTEHVQLLQVIKKTETD MSLHPLLQEIYKDLY TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Huntington's disease, Pathways in cancer, PPAR signaling pathway, Thyroid cancer

Gene Information

• Gene Name: PPARG peroxisome proliferator activated receptor gamma [ Homo sapiens (human) ]
• Official Symbol: PPARG
• Synonyms: GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
• Gene ID: 5468
• mRNA Refseq: NM_015869.5
• Protein Refseq: NP_056953.2
• MIM: 601487
• UniProt ID: P37231