Recombinant Full Length Human RCVRN Protein, C-Flag-tagged

• Cat.No.: RCVRN-1037HFL
• Product Overview: Recombinant Full Length Human RCVRN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 22.9 kDa
• AA Sequence: MGNSKSGALSKEILEELQLNTKFSE EELCSWYQSFLKDCPTGRITQQQFQ SIYAKFFPDTDPKAYAQHVF RSFDSNLDGTLDFKEYVIALHMTTA GKTNQKLEWAFSLYDVDGNGTISKN EVLEIVMAIFKMITPEDVKL
  LPDDENTPEKRAEKIWKYFGKNDDD KLTEKEFIEGTLANKEILRLIQFEP QKVKEKMKNATRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: RCVRN recoverin [ Homo sapiens (human) ]
• Official Symbol: RCVRN
• Synonyms: RCV1
• Gene ID: 5957
• mRNA Refseq: NM_002903.3
• Protein Refseq: NP_002894.1
• MIM: 179618
• UniProt ID: P35243

Reviews

02/16/2020

Whether investigating metabolic pathways, studying enzymatic activity, or exploring drug targets, this protein offers versatility and reliability, allowing for accurate and meaningful data collection.

05/29/2018

In addition to the remarkable protein quality, the manufacturer provides excellent technical support, proving to be a valuable resource when troubleshooting experimental challenges.

06/24/2016

Incorporating this protein into scientific investigations undoubtedly enhances the reliability and effectiveness of research endeavors.

Q&As

Are there any specific populations that may benefit more from RCVRN-targeted therapies?

Individuals with genetic mutations affecting RCVRN and those with early-stage retinal diseases may potentially benefit more from targeted therapies.

How does the expression of RCVRN change with age, and does this have implications for age-related vision disorders?

The expression of RCVRN may change with age, and understanding these changes can provide insights into age-related vision disorders.

How is the level of RCVRN expression correlated with the progression of certain retinal disorders?

Changes in RCVRN expression levels may correlate with the progression of retinal disorders, serving as a potential indicator of disease severity.

Are there ongoing clinical trials exploring the use of RCVRN-based therapies?

Some clinical trials are investigating the safety and efficacy of gene therapies targeting the RCVRN gene for treating specific eye conditions.

How might the manipulation of RCVRN expression offer therapeutic benefits for patients with vision impairments?

Modulating RCVRN expression could potentially restore or enhance photoreceptor function, providing therapeutic benefits for vision-impaired individuals.