Recombinant Full Length Human RIPK1 Protein, N-His-tagged

• Cat.No.: RIPK1-14HFL
• Product Overview: Recombinant Full Length Human RIPK1 Protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Description: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 75.8 kDa
• AA Sequence: A DNA sequence encoding human full-length RIPK1.
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

Gene Information

• Gene Name: RIPK1 receptor interacting serine/threonine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: RIPK1
• Synonyms: RIP; RIP1; AIEFL; IMD57; RIP-1
• Gene ID: 8737
• mRNA Refseq: NM_003804.6
• Protein Refseq: NP_003795.2
• MIM: 603453
• UniProt ID: Q13546

Reviews

02/26/2022

The proteins accepted were of very high purity and were put into experiments with satisfactory results.

03/14/2021

Customer service was patient, prompt and accurate in answering my queries.

11/23/2020

Prompt delivery, which helped me to obtain satisfactory experimental results in a short time.

Q&As

What is the relationship between RIPK1 and necrotic apoptosis?

RIPK1 is one of the most critical intracellular signaling factors mediating necrotic apoptosis.

What is the relationship between Necrostatin-1 and RIPK1?

Necrostatin-1 blocks RIPK1 phosphorylation.

What are the effects of inhibiting RIPK1 expression?

Inhibition of RIPK1 reduces astrocyte proliferation and glial scar formation and promotes recovery of brain function.

RIPK1 is closely associated with the study of which diseases?

RIPK1 is closely related to the study of stroke, neurodegenerative diseases, autoimmune diseases and other diseases.