Recombinant Full Length Human SGCG Protein, C-Flag-tagged

• Cat.No.: SGCG-1905HFL
• Product Overview: Recombinant Full Length Human SGCG Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 32.2 kDa
• AA Sequence: MVREQYTTATEGICIERPENQYVYK IGIYGWRKRCLYLFVLLLLIILVVN LALTIWILKVMWFSPAGMGH LCVTKDGLRLEGESEFLFPLYAKEI HSRVDSSLLLQSTQNVTVNARNSEG EVTGRLKVGPKMVEVQNQQF QINSNDGKPLFTVDEKEVVVGTDKL RVTGPEGALFEHSVETPLVRADPFQ DLRLESPTRSLSMDAPRGVH IQAHAGKIEALSQMDILFHSSDGML VLDAETVCLPKLVQGTWGPSGSSQS LYEICVCPDGKLYLSVAGVS TTCQEHSHICL TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis

Gene Information

• Gene Name: SGCG sarcoglycan gamma [ Homo sapiens (human) ]
• Official Symbol: SGCG
• Synonyms: A4; MAM; DMDA; SCG3; 35DAG; DAGA4; DMDA1; LGMD2C; LGMDR5; SCARMD2; gamma-SG
• Gene ID: 6445
• mRNA Refseq: NM_000231.3
• Protein Refseq: NP_000222.2
• MIM: 608896
• UniProt ID: Q13326