| Description : |
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
101.310kDa |
| Protein Length : |
684 amino acids |
| AA Sequence : |
MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHVNG KTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETL HLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTV FLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVG GEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSD QLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFP QNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQF YVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGF ESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSG KRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSY YLYMCDKVVAPNVSLTSAVSQSKELTKTEASKSISRQSEK AHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASI SNNSTSKRKSESATCNLVRDINKVGIGLVAAASSPLLVKD VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVK MLSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQ KDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRL DHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSK TAKE |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
