| Description : |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
Insect cells |
| Species : |
Human |
| Tag : |
C-His,C-Flag |
| Form : |
Sterile 25mM Hepes, 0.1mM EDTA, 10% Glycerol, 350mM NaCl, pH7.6. |
| Molecular Mass : |
186 kDa |
| AA Sequence : |
MSTPDPPLGGTPRPGPSPGPGPSPG AMLGPSPGPSPGSAHSMMGPSPGPP SAGHPIPTQGPGGYPQDNMHQMHKP MESMHEKGMSDDPRYNQMKGMGMRS GGHAGMGPPPSPMDQHSQGYPSPLG GSEHASSPVPASGPSSGPQMSSGPG GAPLDGADPQALGQQNRGPTPFNQN QLHQLRAQIMAYKMLARGQPLPDHL QMAVQGKRPMPGMQQQMPTLPPPSV SATGPGPGPGPGPGPGPGPAPPNYS RPHGMGGPNMPPPGPSGVPPGMPGQ PPGGPPKPWPEGPMANAAAPTSTPQ KLIPPQPTGRPSPAPPAVPPAASPV MPPQTQSPGQPAQPAPMVPLHQKQS RITPIQKPRGLDPVEILQEREYRLQ ARIAHRIQELENLPGSLAGDLRTKA TIELKALRLLNFQRQLRQEVVVCMR RDTALETALNAKAYKRSKRQSLREA RITEKLEKQQKIEQERKRRQKHQEY LNSILQHAKDFKEYHRSVTGKIQKL TKAVATYHANTEREQKKENERIEKE RMRRLMAEDEEGYRKLIDQKKDKRL AYLLQQTDEYVANLTELVRQHKAAQ VAKEKKKKKKKKKAENAEGQTPAIG PDGEPLDETSQMSDLPVKVIHVESG KILTGTDAPKAGQLEAWLEMNPGYE VAPRSDSEESGSEEEEEEEEEEQPQ AAQPPTLPVEEKKKIPDPDSDDVSE VDARHIIENAKQDVDDEYGVSQALA RGLQSYYAVAHAVTERVDKQSALMV NGVLKQYQIKGLEWLVSLYNNNLNG ILADEMGLGKTIQTIALITYLMEHK RINGPFLIIVPLSTLSNWAYEFDKW APSVVKVSYKGSPAARRAFVPQLRS GKFNVLLTTYEYIIKDKHILAKIRW KYMIVDEGHRMKNHHCKLTQVLNTH YVAPRRLLLTGTPLQNKLPELWALL NFLLPTIFKSCSTFEQWFNAPFAMT GEKVDLNEEETILIIRRLHKVLRPF LLRRLKKEVEAQLPEKVEYVIKCDM SALQRVLYRHMQAKGVLLTDGSEKD KKGKGGTKTLMNTIMQLRKICNHPY MFQHIEESFSEHLGFTGGIVQGLDL YRASGKFELLDRILPKLRATNHKVL LFCQMTSLMTIMEDYFAYRGFKYLR LDGTTKAEDRGMLLKTFNEPGSEYF IFLLSTRAGGLGLNLQSADTVIIFD SDWNPHQDLQAQDRAHRIGQQNEVR VLRLCTVNSVEEKILAAAKYKLNVD QKVIQAGMFDQKSSSHERRAFLQAI LEHEEQDESRHCSTGSGSASFAHTA PPPAGVNPDLEEPPLKEEDEVPDDE TVNQMIARHEEEFDLFMRMDLDRRR EEARNPKRKPRLMEEDELPSWIIKD DAEVERLTCEEEEEKMFGRGSRHRK EVDYSDSLTEKQWLKAIEEGTLEEI EEEVRQKKSSRKRKRDSDAGSSTPT TSTRSRDKDDESKKQKKRGRPPAEK LSPNPPNLTKKMKKIVDAVIKYKDS SSGRQLSEVFIQLPSRKELPEYYEL IRKPVDFKKIKERIRNHKYRSLNDL EKDVMLLCQNAQTFNLEGSLIYEDS IVLQSVFTSVRQKIEKEDDSEGEES EEEEEGEEEGSESESRSVKVKIKLG RKEKAQDRLKGGRRRPSRGSRAKPV VSDDDSEEEQEEDRSGSGSEEDHHH HHHDYKDDDDK |
| Storage : |
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.46 mg/ml |
