| Description : |
The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
120.120kDa inclusive of tags |
| Protein Length : |
855 amino acids |
| AA Sequence : |
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLP VNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQ YRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFS IPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFP TDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYN TLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNT ERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKD YVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGF LAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDE QGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHI CGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHD QSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGA LILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDS CQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT RLPLFRDWIKENTGV |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
| Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |
