Recombinant Full Length Human STAT4 Protein, C-Flag-tagged

• Cat.No.: STAT4-1745HFL
• Product Overview: Recombinant Full Length Human STAT4 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 85.8 kDa
• AA Sequence: MSQWNQVQQLEIKFLEQVDQFYDDN FPMEIRHLLAQWIENQDWEAASNNE TMATILLQNLLIQLDEQLGR VSKEKNLLLIHNLKRIRKVLQGKFH GNPMHVAVVISNCLREERRILAAAN MPVQGPLEKSLQSSSVSERQ RNVEHKVAAIKNSVQMTEQDTKYLE DLQDEFDYRYKTIQTMDQSDKNSAM VNQEVLTLQEMLNSLDFKRK EALSKMTQIIHETDLLMNTMLIEEL QDWKRRQQIACIGGPLHNGLDQLQN CFTLLAESLFQLRRQLEKLE EQSTKMTYEGDPIPMQRTHMLERVT FLIYNLFKNSFVVERQPCMPTHPQR PLVLKTLIQFTVKLRLLIKL PELNYQVKVKASIDKNVSTLSNRRF VLCGTNVKAMSIEESSNGSLSVEFR HLQPKEMKSSAGGKGNEGCH MVTEELHSITFETQICLYGLTIDLE TSSLPVVMISNVSQLPNAWASIIWY NVSTNDSQNLVFFNNPPPAT LSQLLEVMSWQFSSYVGRGLNSDQL HMLAEKLTVQSSYSDGHLTWAKFCK EHLPGKSFTFWTWLEAILDL IKKHILPLWIDGYVMGFVSKEKERL LLKDKMPGTFLLRFSESHLGGITFT WVDHSESGEVRFHSVEPYNK GRLSALPFADILRDYKVIMAENIPE NPLKYLYPDIPKDKAFGKHYSSQPC EVSRPTERGDKGYVPSVFIP
  ISTIRSDSTEPHSPSDLLPMSPSVY AVLRENLSPTTIETAMKSPYSAETR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Jak-STAT signaling pathway

Gene Information

• Gene Name: STAT4 signal transducer and activator of transcription 4 [ Homo sapiens (human) ]
• Official Symbol: STAT4
• Synonyms: SLEB11
• Gene ID: 6775
• mRNA Refseq: NM_003151.4
• Protein Refseq: NP_003142.1
• MIM: 600558
• UniProt ID: Q14765