Recombinant Full Length Human SYN1 Protein, C-Flag-tagged

• Cat.No.: SYN1-461HFL
• Product Overview: Recombinant Full Length Human SYN1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 73.9 kDa
• AA Sequence: MNYLRRRLSDSNFMANLPNGYMTDL QRPQPPPPPPGAHSPGATPGPGTAT AERSSGVAPAASPAAPSPGS SGGGGFFSSLSNAVKQTTAAAAATF SEQVGGGSGGAGRGGAASRVLLVID EPHTDWAKYFKGKKIHGEID IKVEQAEFSDLNLVAHANGGFSVDM EVLRNGVKVVRSLKPDFVLIRQHAF SMARNGDYRSLVIGLQYAGI PSVNSLHSVYNFCDKPWVFAQMVRL HKKLGTEEFPLIDQTFYPNHKEMLS STTYPVVVKMGHAHSGMGKV KVDNQHDFQDIASVVALTKTYATAE PFIDAKYDVRVQKIGQNYKAYMRTS VSGNWKTNTGSAMLEQIAMS DRYKLWVDTCSEIFGGLDICAVEAL HGKDGRDHIIEVVGSSMPLIGDHQD EDKQLIVELVVNKMAQALPR QRQRDASPGRGSHGQTPSPGALPLG RQTSQQPAGPPAQQRPPPQGGPPQP GPGPQRQGPPLQQRPPPQGQ QHLSGLGPPAGSPLPQRLPSPTSAP QQPASQAAPPTQGQGRQSRPVAGGP GAPPAARPPASPSPQRQAGP PQATRQTSVSGPAPPKASGAPPGGQ QRQGPPQKPPGPAGPTRQASQAGPV PRTGPPTTQQPRPSGPGPAG RPKPQLAQKPSQDVPPPATAAAGGP PHPQLNKSQSLTNAFNLPEPAPPRP SLSQDEVKAETIRSLRKSFA
  SLFSDTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: SYN1 synapsin I [ Homo sapiens (human) ]
• Official Symbol: SYN1
• Synonyms: SYNI; EPILX; MRX50; SYN1a; SYN1b; EPILX1
• Gene ID: 6853
• mRNA Refseq: NM_006950.3
• Protein Refseq: NP_008881.2
• MIM: 313440
• UniProt ID: P17600