Recombinant Full Length Human THBS1 Protein, C-Flag-tagged

• Cat.No.: THBS1-60HFL
• Product Overview: Recombinant Full Length Human THBS1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 127.4 kDa
• AA Sequence: MGLAWGLGVLFLMHVCGTNRIPESG GDNSVFDIFELTGAARKGSGRRLVK GPDPSSPAFRIEDANLIPPV PDDKFQDLVDAVRAEKGFLLLASLR QMKKTRGTLLALERKDHSGQVFSVV SNGKAGTLDLSLTVQGKQHV VSVEEALLATGQWKSITLFVQEDRA QLYIDCEKMENAELDVPIQSVFTRD LASIARLRIAKGGVNDNFQG VLQNVRFVFGTTPEDILRNKGCSSS TSVLLTLDNNVVNGSSPAIRTNYIG HKTKDLQAICGISCDELSSM VLELRGLRTIVTTLQDSIRKVTEEN KELANELRRPPLCYHNGVQYRNNEE WTVDSCTECHCQNSVTICKK VSCPIMPCSNATVPDGECCPRCWPS DSADDGWSPWSEWTSCSTSCGNGIQ QRGRSCDSLNNRCEGSSVQT RTCHIQECDKRFKQDGGWSHWSPWS SCSVTCGDGVITRIRLCNSPSPQMN GKPCEGEARETKACKKDACP INGGWGPWSPWDICSVTCGGGVQKR SRLCNNPTPQFGGKDCVGDVTENQI CNKQDCPIDGCLSNPCFAGV KCTSYPDGSWKCGACPPGYSGNGIQ CTDVDECKEVPDACFNHNGEHRCEN TDPGYNCLPCPPRFTGSQPF GQGVEHATANKQVCKPRNPCTDGTH DCNKNAKCNYLGHYSDPMYRCECKP GYAGNGIICGEDTDLDGWPN ENLVCVANATYHCKKDNCPNLPNSG QEDYDKDGIGDACDDDDDNDKIPDD RDNCPFHYNPAQYDYDRDDV GDRCDNCPYNHNPDQADTDNNGEGD ACAADIDGDGILNERDNCQYVYNVD QRDTDMDGVGDQCDNCPLEH NPDQLDSDSDRIGDTCDNNQDIDED GHQNNLDNCPYVPNANQADHDKDGK GDACDHDDDNDGIPDDKDNC RLVPNPDQKDSDGDGRGDACKDDFD HDSVPDIDDICPENVDISETDFRRF QMIPLDPKGTSQNDPNWVVR HQGKELVQTVNCDPGLAVGYDEFNA VDFSGTFFINTERDDDYAGFVFGYQ SSSRFYVVMWKQVTQSYWDT NPTRAQGYSGLSVKVVNSTTGPGEH LRNALWHTGNTPGQVRTLWHDPRHI GWKDFTAYRWRLSHRPKTGF
  IRVVMYEGKKIMADSGPIYDKTYAG GRLGLFVFSQEMVFFSDLKYECRDP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Bladder cancer, ECM-receptor interaction, Focal adhesion, p53 signaling pathway, TGF-beta signaling pathway

Gene Information

• Gene Name: THBS1 thrombospondin 1 [ Homo sapiens (human) ]
• Official Symbol: THBS1
• Synonyms: TSP; THBS; TSP1; TSP-1; THBS-1
• Gene ID: 7057
• mRNA Refseq: NM_003246.4
• Protein Refseq: NP_003237.2
• MIM: 188060
• UniProt ID: P07996