Recombinant Full Length Human TLL1 Protein, C-Flag-tagged

• Cat.No.: TLL1-1333HFL
• Product Overview: Recombinant Full Length Human TLL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 114.5 kDa
• AA Sequence: MGLGTLSPRMLVWLVASGIVFYGEL WVCAGLDYDYTFDGNEEDKTETIDY KDPCKAAVFWGDIALDDEDL NIFQIDRTIDLTQNPFGNLGHTTGG LGDHAMSKKRGALYQLIDRIRRIGF GLEQNNTVKGKVPLQFSGQN EKNRVPRAATSRTERIWPGGVIPYV IGGNFTGSQRAMFKQAMRHWEKHTC VTFIERSDEESYIVFTYRPC GCCSYVGRRGNGPQAISIGKNCDKF GIVVHELGHVIGFWHEHTRPDRDNH VTIIRENIQPGQEYNFLKME PGEVNSLGERYDFDSIMHYARNTFS RGMFLDTILPSRDDNGIRPAIGQRT RLSKGDIAQARKLYRCPACG ETLQESNGNLSSPGFPNGYPSYTHC IWRVSVTPGEKIVLNFTTMDLYKSS LCWYDYIEVRDGYWRKSPLL GRFCGDKLPEVLTSTDSRMWIEFRS SSNWVGKGFAAVYEAICGGEIRKNE GQIQSPNYPDDYRPMKECVW KITVSESYHVGLTFQSFEIERHDNC AYDYLEVRDGTSENSPLIGRFCGYD KPEDIRSTSNTLWMKFVSDG TVNKAGFAANFFKEEDECAKPDRGG CEQRCLNTLGSYQCACEPGYELGPD RRSCEAACGGLLTKLNGTIT TPGWPKEYPPNKNCVWQVVAPTQYR ISVKFEFFELEGNEVCKYDYVEIWS GLSSESKLHGKFCGAEVPEV ITSQFNNMRIEFKSDNTVSKKGFKA HFFSDKDECSKDNGGCQHECVNTMG SYMCQCRNGFVLHDNKHDCK EAECEQKIHSPSGLITSPNWPDKYP SRKECTWEISATPGHRIKLAFSEFE IEQHQECAYDHLEVFDGETE KSPILGRLCGNKIPDPLVATGNKMF VRFVSDASVQRKGFQATHSTECGGR LKAESKPRDLYSHAQFGDNN YPGQVDCEWLLVSERGSRLELSFQT FEVEEEADCGYDYVELFDGLDSTAV GLGRFCGSGPPEEIYSIGDS
  VLIHFHTDDTINKKGFHIRYKSIRY PDTTHTKKTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protease, Secreted Protein

Gene Information

• Gene Name: TLL1 tolloid like 1 [ Homo sapiens (human) ]
• Official Symbol: TLL1
• Synonyms: TLL; ASD6
• Gene ID: 7092
• mRNA Refseq: NM_012464.5
• Protein Refseq: NP_036596.3
• MIM: 606742
• UniProt ID: O43897